tert-butyl benzyloxy(3-(diethoxyphosphoryl)propyl)carbamate

Base Information

• Chemical Name: tert-butyl benzyloxy(3-(diethoxyphosphoryl)propyl)carbamate
• CAS No.: 1401988-87-1
• Molecular Formula: C₁₉H₃₂NO₆P
• Molecular Weight: 401.44
• Mol file: 1401988-87-1.mol

Synonyms:tert-butyl benzyloxy(3-(diethoxyphosphoryl)propyl)carbamate

Chemical Property of tert-butyl benzyloxy(3-(diethoxyphosphoryl)propyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl benzyloxy(3-(diethoxyphosphoryl)propyl)carbamate

There total 1 articles about tert-butyl benzyloxy(3-(diethoxyphosphoryl)propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

diethyl 3-(bromopropyl)phosphonic acid (1186-10-3) + tert-butyl N-(benzyloxy)carbamate (79722-21-7) → tert-butyl benzyloxy(3-(diethoxyphosphoryl)propyl)carbamate (1401988-87-1)

Guidance literature:

tert-butyl N-(benzyloxy)carbamate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Inert atmosphere;

diethyl 3-(bromopropyl)phosphonic acid; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 16h;

DOI:10.1016/j.tet.2012.11.049

Reference yield:

tert-butyl benzyloxy(3-(diethoxyphosphoryl)propyl)carbamate (1401988-87-1) → [3-[acetyl(phenylmethoxy)amino]propyl]phosphonic acid diethyl ester (581106-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 7 h / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.tet.2012.11.049

Reference yield:

tert-butyl benzyloxy(3-(diethoxyphosphoryl)propyl)carbamate (1401988-87-1) → diethyl [3-((N-benzyloxy)(N-formyl)amino)]propylphosphonate (1350649-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 7 h / 20 °C

2.1: formic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

With formic acid; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.tet.2012.11.049

upstream raw materials:

diethyl 3-(bromopropyl)phosphonic acid

tert-butyl N-(benzyloxy)carbamate

Downstream raw materials:

[3-[acetyl(phenylmethoxy)amino]propyl]phosphonic acid diethyl ester

diethyl [3-((N-benzyloxy)(N-formyl)amino)]propylphosphonate