rac-5-(hex-5-enyl)-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-7-ol

Base Information

Chemical Name:rac-5-(hex-5-enyl)-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-7-ol
CAS No.:1447450-46-5
Molecular Formula:C₂₇H₃₁N₃O
Molecular Weight:413.563
Hs Code.:

Synonyms:rac-5-(hex-5-enyl)-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-7-ol

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Chemical Property of rac-5-(hex-5-enyl)-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-7-ol

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Technology Process of rac-5-(hex-5-enyl)-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-7-ol

There total 8 articles about rac-5-(hex-5-enyl)-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1447306-89-9
rac-tert-butyl 7-hydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate

: 1447450-46-5
rac-5-(hex-5-enyl)-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1: citric acid / water; acetonitrile / 48 h / 40 °C

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; citric acid; In water; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 2,3-di-p-tolylpyrido[2,3-b]pyrazine acetic acid salt

: 1447450-46-5
rac-5-(hex-5-enyl)-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-7-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 168 h / 20 °C / 75.01 Torr

2.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere

2.2: 20 - 40 °C

3.1: 4-methylmorpholine N-oxide / water; acetone / 40 °C / Inert atmosphere

4.1: tetrahydrofuran / 3 h / Reflux

5.1: tri-n-butyl-tin hydride / toluene / 8 h / Reflux

6.1: citric acid / water; acetonitrile / 48 h / 40 °C

7.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; tri-n-butyl-tin hydride; sodium tris(acetoxy)borohydride; 4-methylmorpholine N-oxide; citric acid; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane; acetone; toluene; acetonitrile;

Reference yield:

: 3457-48-5
1,2-di(4-methylphenyl)-1,2-ethanedione

: 1447450-46-5
rac-5-(hex-5-enyl)-2,3-di-p-tolyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-7-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / 1.5 h / 85 °C

2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 168 h / 20 °C / 75.01 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere

3.2: 20 - 40 °C

4.1: 4-methylmorpholine N-oxide / water; acetone / 40 °C / Inert atmosphere

5.1: tetrahydrofuran / 3 h / Reflux

6.1: tri-n-butyl-tin hydride / toluene / 8 h / Reflux

7.1: citric acid / water; acetonitrile / 48 h / 40 °C

8.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; tri-n-butyl-tin hydride; sodium tris(acetoxy)borohydride; 4-methylmorpholine N-oxide; citric acid; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane; acetone; toluene; acetonitrile;