2-{3-[(3-methyl-but-2-enyl)-(toluene-4-sulfonyl)-amino]-propyl}-2-phenylselanyl-malonic acid dimethyl ester

Base Information

Chemical Name:2-{3-[(3-methyl-but-2-enyl)-(toluene-4-sulfonyl)-amino]-propyl}-2-phenylselanyl-malonic acid dimethyl ester
CAS No.:867039-57-4
Molecular Formula:C₂₆H₃₃NO₆SSe
Molecular Weight:566.577
Hs Code.:

Synonyms:2-{3-[(3-methyl-but-2-enyl)-(toluene-4-sulfonyl)-amino]-propyl}-2-phenylselanyl-malonic acid dimethyl ester

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Chemical Property of 2-{3-[(3-methyl-but-2-enyl)-(toluene-4-sulfonyl)-amino]-propyl}-2-phenylselanyl-malonic acid dimethyl ester

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Technology Process of 2-{3-[(3-methyl-but-2-enyl)-(toluene-4-sulfonyl)-amino]-propyl}-2-phenylselanyl-malonic acid dimethyl ester

There total 5 articles about 2-{3-[(3-methyl-but-2-enyl)-(toluene-4-sulfonyl)-amino]-propyl}-2-phenylselanyl-malonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 867039-52-9
2-[4-aza-7-methyl-4-(p-toluenesulfonyl)oct-6-enyl]malonic acid dimethyl ester

: 5707-04-0
Phenylselenyl chloride

: 867039-57-4
2-{3-[(3-methyl-but-2-enyl)-(toluene-4-sulfonyl)-amino]-propyl}-2-phenylselanyl-malonic acid dimethyl ester

Guidance literature:: 2-[4-aza-7-methyl-4-(p-toluenesulfonyl)oct-6-enyl]malonic acid dimethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 25 ℃; for 0.5h;

Phenylselenyl chloride; In tetrahydrofuran; at -78 - 25 ℃; for 18h;
DOI:10.1016/j.tetlet.2005.08.002

Reference yield:

: 867039-51-8
N-(3-bromopropyl)-4-methyl-N-(3-methylbut-2-enyl)benzenesulfonamide

: 867039-57-4
2-{3-[(3-methyl-but-2-enyl)-(toluene-4-sulfonyl)-amino]-propyl}-2-phenylselanyl-malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 78 percent / NaHMDS / tetrahydrofuran / 18 h / 25 °C

2.1: LDA / tetrahydrofuran / 0.5 h / -78 - 25 °C

2.2: 94 percent / tetrahydrofuran / 18 h / -78 - 25 °C

With sodium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2005.08.002

Reference yield:

: 13379-98-1
3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol

: 867039-57-4
2-{3-[(3-methyl-but-2-enyl)-(toluene-4-sulfonyl)-amino]-propyl}-2-phenylselanyl-malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 93 percent / Cs₂CO₃ / acetonitrile / 18 h / 25 °C

2.1: 94 percent / PPh₃; CBr₄ / CH₂Cl₂ / 2 h / 25 °C

3.1: 78 percent / NaHMDS / tetrahydrofuran / 18 h / 25 °C

4.1: LDA / tetrahydrofuran / 0.5 h / -78 - 25 °C

4.2: 94 percent / tetrahydrofuran / 18 h / -78 - 25 °C

With carbon tetrabromide; sodium hexamethyldisilazane; caesium carbonate; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.tetlet.2005.08.002