(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

Base Information

Chemical Name:(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea
CAS No.:1429638-92-5
Molecular Formula:C₂₁H₂₅N₅O₂S
Molecular Weight:411.528
Hs Code.:

Synonyms:(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

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Chemical Property of (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

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Technology Process of (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

There total 6 articles about (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 874297-79-7
1-cyclopropyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

: 1429639-71-3
2-chloro-5,7-dihydro-4-((S)-3-methylmorpholino)thieno[3,4-d]pyrimidine

: 1429638-92-5
(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,2-dimethoxyethane; water; at 70 ℃; Inert atmosphere;

Reference yield:

: 5719-20-0
5H,7H-2-ethylthiodihydrothieno<3,4-d>pyrimidin-4-one

: 1429638-92-5
(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: water; hydrogenchloride; acetic acid / Reflux

2: P,P-dichlorophenylphosphine oxide / 135 - 165 °C

3: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

4: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 70 °C / Inert atmosphere

With P,P-dichlorophenylphosphine oxide; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; sodium carbonate; acetic acid; triethylamine; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 4: |Suzuki Coupling;

Reference yield:

: 74901-71-6
2,4-dichloro-5,7-dihydrothieno[3,4-d]pyrimidine

: 1429638-92-5
(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 70 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;