74901-71-6

Basic information

• Product Name: 2,4-dichloro-5,7-dihydrothieno[3,4-d]pyriMidine
• Synonyms: 2,4-dichloro-5,7-dihydrothieno[3,4-d]pyriMidine;2,4-dichloro-5H,7H-thieno[3,4-d]pyrimidine
• CAS NO: 74901-71-6
• Molecular Formula: C₆H₄Cl₂N₂S
• Molecular Weight: 207.08036
• Mol File: 74901-71-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 371.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.613±0.06 g/cm3(Predicted)
• PKA: -3.46±0.20(Predicted)
• CAS DataBase Reference: 2,4-dichloro-5,7-dihydrothieno[3,4-d]pyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-5,7-dihydrothieno[3,4-d]pyriMidine(74901-71-6)
• EPA Substance Registry System: 2,4-dichloro-5,7-dihydrothieno[3,4-d]pyriMidine(74901-71-6)

Safety Data

• Hazardous Substances Data: 74901-71-6(Hazardous Substances Data)

Usage

General Description

2,4-dichloro-5,7-dihydrothieno[3,4-d]pyriMidine is a chemical compound with the molecular formula C8H6Cl2N2S. It is a heterocyclic compound that contains chlorine atoms and a thieno ring structure. 2,4-dichloro-5,7-dihydrothieno[3,4-d]pyriMidine is often used as a building block in pharmaceutical synthesis and can be found in various drug molecules. It has also been studied for its potential biological activities and is of interest in medicinal chemistry for its potential applications in drug development. However, it is important to handle this compound with caution as it may have potential health hazards and should be used in accordance with proper safety protocols.

Upstream product

• 5719-34-6 5,7-dihydrothieno[3,4-d]pyrimidine-2,4-diol 
• 2689-68-1 methyl 4-oxotetrahydrothiophene-3-carboxylate 
• 7400-45-5 dimethyl-3-thiaadipate 
• 5719-34-6 5H,7H-2-dihydrothieno<3,4-d>pyrimidine-2,4-dione 
• 5719-20-0 5H,7H-2-ethylthiodihydrothieno<3,4-d>pyrimidin-4-one 

Downstream Products

• 1429638-92-5 (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea 
• 1429638-93-6 (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea 

Relevant articles and documents

TREATMENT OF INFECTIOUS DISEASES WITH GLUCOSE UPTAKE INHIBITORS

Provided are methods of treating infectious diseases in mammals comprising administering a compound that inhibits glucose uptake. Particular infectious diseases that may be treated include malaria, leishmaniasis, African trypanosomiasis, tuberculosis, HIV, HCMV or herpes virus. In a first aspect, the invention features a method of treating infectious diseases in a mammal, comprising administering to a mammalian subject in need thereof a therapeutically effective amount of a compound or prodrug thereof, or pharmaceutically acceptable salt or ester of said compound or prodrug, wherein the compound is an inhibitor of glucose uptake.

MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS

The invention relates to compounds of formula (I) wherein m, o, Ra, Rb, R1 and T1 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments