1-(4-methoxyphenyl)-3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)urea

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)urea
• CAS No.: 1443687-76-0
• Molecular Formula: C₂₅H₃₈N₄O₃
• Molecular Weight: 442.602
• Mol file: 1443687-76-0.mol

Synonyms:1-(4-methoxyphenyl)-3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)urea

Chemical Property of 1-(4-methoxyphenyl)-3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-methoxyphenyl)-3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)urea

There total 2 articles about 1-(4-methoxyphenyl)-3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetradecanoyl chloride (112-64-1) → 1-(4-methoxyphenyl)-3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)urea (1443687-76-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / acetonitrile / 2.25 h / 0 - 10 °C

1.2: 16 h / 20 °C

2.1: potassium tert-butylate / ethanol / 72 h / Reflux

3.1: triethylamine / tetrahydrofuran / 18 h / Reflux

With potassium tert-butylate; triethylamine; In tetrahydrofuran; ethanol; acetonitrile;

DOI:10.1039/c2ra22715k

Reference yield:

3-oxo-hexadecanoic acid ethyl ester (62148-72-5) → 1-(4-methoxyphenyl)-3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)urea (1443687-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / ethanol / 72 h / Reflux

2: triethylamine / tetrahydrofuran / 18 h / Reflux

With potassium tert-butylate; triethylamine; In tetrahydrofuran; ethanol;

DOI:10.1039/c2ra22715k

Reference yield: 93.0%

1-(4-methoxyphenyl)-3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)urea (1443687-76-0) → 1-(4-hydroxyphenyl)-3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)urea (1443687-78-2)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 20h;

DOI:10.1039/c2ra22715k

upstream raw materials:

tetradecanoyl chloride

3-oxo-hexadecanoic acid ethyl ester

Downstream raw materials:

1-(4-hydroxyphenyl)-3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)urea

4-(3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)ureido)phenylundec-10-enoate