{(3-benzyloxy-2-tert-butoxycarbonylamino-propyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid ethyl ester

Base Information

Chemical Name:{(3-benzyloxy-2-tert-butoxycarbonylamino-propyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid ethyl ester
CAS No.:909866-94-0
Molecular Formula:C₂₆H₃₆N₄O₈
Molecular Weight:532.594
Hs Code.:

{(3-benzyloxy-2-<i>tert</i>-butoxycarbonylamino-propyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-acetyl]-amino}-acetic acid ethyl ester

Synonyms:{(3-benzyloxy-2-tert-butoxycarbonylamino-propyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid ethyl ester

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Chemical Property of {(3-benzyloxy-2-tert-butoxycarbonylamino-propyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid ethyl ester

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Technology Process of {(3-benzyloxy-2-tert-butoxycarbonylamino-propyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid ethyl ester

There total 4 articles about {(3-benzyloxy-2-tert-butoxycarbonylamino-propyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 909866-93-9
N-tert-butyloxycarbonyl-1-(O-benzyloxymethyl)-aminoethylglycine ethyl ester

: 20924-05-4
thymidyl acetic acid

: 909866-94-0
{(3-benzyloxy-2-tert-butoxycarbonylamino-propyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid ethyl ester

Guidance literature:: With 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 50 ℃; for 24h;
DOI:10.1021/ja0625576

Reference yield:

: 23680-31-1
BOC-O-benzyl-L-serine

: 909866-94-0
{(3-benzyloxy-2-tert-butoxycarbonylamino-propyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 97 percent / N-methyl morpholine; isobutyl chloroformate / CH₂Cl₂ / 14 h / 20 °C

2.1: lithium aluminum hydride / tetrahydrofuran / 1 h / 0 °C

3.1: methanol; various solvent(s) / 4 h / 4 °C

3.2: 1.6 g / acetic acid; NaBH₃CN / 0.5 h

4.1: 62 percent / DCC; 3-hydroxy-1,2,3-benzotriazin-4(3H)-one / dimethylformamide / 24 h / 50 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0625576

Reference yield:

: 79069-54-8
(S)-2-(t-butoxycarbonylamino)-3-phenylmetoxy-1-propanal

: 909866-94-0
{(3-benzyloxy-2-tert-butoxycarbonylamino-propyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; various solvent(s) / 4 h / 4 °C

1.2: 1.6 g / acetic acid; NaBH₃CN / 0.5 h

2.1: 62 percent / DCC; 3-hydroxy-1,2,3-benzotriazin-4(3H)-one / dimethylformamide / 24 h / 50 °C

With 3-hydroxy-3,4-dihydrobenzotriazine-4-one; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja0625576