N-tert-butyloxycarbonyl-1-(O-benzyloxymethyl)-aminoethylglycine ethyl ester

Base Information

Chemical Name:N-tert-butyloxycarbonyl-1-(O-benzyloxymethyl)-aminoethylglycine ethyl ester
CAS No.:909866-93-9
Molecular Formula:C₁₉H₃₀N₂O₅
Molecular Weight:366.458
Hs Code.:

Synonyms:N-tert-butyloxycarbonyl-1-(O-benzyloxymethyl)-aminoethylglycine ethyl ester

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Chemical Property of N-tert-butyloxycarbonyl-1-(O-benzyloxymethyl)-aminoethylglycine ethyl ester

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Technology Process of N-tert-butyloxycarbonyl-1-(O-benzyloxymethyl)-aminoethylglycine ethyl ester

There total 3 articles about N-tert-butyloxycarbonyl-1-(O-benzyloxymethyl)-aminoethylglycine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 79069-54-8
(S)-2-(t-butoxycarbonylamino)-3-phenylmetoxy-1-propanal

: 459-73-4
GlyOEt*HCl

: 909866-93-9
N-tert-butyloxycarbonyl-1-(O-benzyloxymethyl)-aminoethylglycine ethyl ester

Guidance literature:: (S)-2-(t-butoxycarbonylamino)-3-phenylmetoxy-1-propanal; GlyOEt*HCl; In methanol; at 4 ℃; for 4h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; acetic acid; In methanol; for 0.5h;
DOI:10.1021/jacs.7b02260

Reference yield:

: 23680-31-1
BOC-O-benzyl-L-serine

: 909866-93-9
N-tert-butyloxycarbonyl-1-(O-benzyloxymethyl)-aminoethylglycine ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 97 percent / N-methyl morpholine; isobutyl chloroformate / CH₂Cl₂ / 14 h / 20 °C

2.1: lithium aluminum hydride / tetrahydrofuran / 1 h / 0 °C

3.1: methanol; various solvent(s) / 4 h / 4 °C

3.2: 1.6 g / acetic acid; NaBH₃CN / 0.5 h

With 4-methyl-morpholine; lithium aluminium tetrahydride; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja0625576

Reference yield:

: 115186-34-0
tert-butyl ((S)-3-(benzyloxy)-1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate

: 909866-93-9
N-tert-butyloxycarbonyl-1-(O-benzyloxymethyl)-aminoethylglycine ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminum hydride / tetrahydrofuran / 1 h / 0 °C

2.1: methanol; various solvent(s) / 4 h / 4 °C

2.2: 1.6 g / acetic acid; NaBH₃CN / 0.5 h

With lithium aluminium tetrahydride; In tetrahydrofuran; methanol;
DOI:10.1021/ja0625576