(tert-butyloxycarbonyl)-L-phenylalanyl-D-prolyl-L-alanyl-α-aminoisobutyric acid methyl ester

Base Information

Chemical Name:(tert-butyloxycarbonyl)-L-phenylalanyl-D-prolyl-L-alanyl-α-aminoisobutyric acid methyl ester
CAS No.:82113-22-2
Molecular Formula:C₂₇H₄₀N₄O₇
Molecular Weight:532.637
Hs Code.:

Synonyms:(tert-butyloxycarbonyl)-L-phenylalanyl-D-prolyl-L-alanyl-α-aminoisobutyric acid methyl ester

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Chemical Property of (tert-butyloxycarbonyl)-L-phenylalanyl-D-prolyl-L-alanyl-α-aminoisobutyric acid methyl ester

Chemical Property:

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Technology Process of (tert-butyloxycarbonyl)-L-phenylalanyl-D-prolyl-L-alanyl-α-aminoisobutyric acid methyl ester

There total 5 articles about (tert-butyloxycarbonyl)-L-phenylalanyl-D-prolyl-L-alanyl-α-aminoisobutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72086-78-3
L-alanyl-α-aminoisobutyric acid methyl ester

: 57225-02-2
N-(tert-butoxycarbonyl)-(S)-phenylalanyl-(R)-proline

: 82113-22-2
(tert-butyloxycarbonyl)-L-phenylalanyl-D-prolyl-L-alanyl-α-aminoisobutyric acid methyl ester

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at -10 ℃; for 1h; Yield given;
DOI:10.1021/jo00136a033

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 82113-22-2
(tert-butyloxycarbonyl)-L-phenylalanyl-D-prolyl-L-alanyl-α-aminoisobutyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline (EEDQ) / ethyl acetate / 3 h / 0 °C

2: 73 percent / 1 N NaOH / methanol

3: dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole monohydrate (HOBt) / dimethylformamide / 1 h / -10 °C

With sodium hydroxide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00136a033

Reference yield:

: 43041-12-9
methyl (2R)-pyrrolidine-2-carboxylate

: 82113-22-2
(tert-butyloxycarbonyl)-L-phenylalanyl-D-prolyl-L-alanyl-α-aminoisobutyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline (EEDQ) / ethyl acetate / 3 h / 0 °C

2: 73 percent / 1 N NaOH / methanol

3: dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole monohydrate (HOBt) / dimethylformamide / 1 h / -10 °C

With sodium hydroxide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00136a033