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43041-12-9 Usage


Methyl D-prolinate, also known as D-Proline Methyl Ester, is an organic compound that serves as a crucial building block in the synthesis of various pharmaceutical compounds. It is a derivative of the naturally occurring amino acid, proline, with a methyl ester group attached to it. This modification enhances its reactivity and compatibility in chemical reactions, making it a valuable component in the development of new drugs.


Used in Pharmaceutical Industry:
Methyl D-prolinate is used as a building block for the synthesis of pharmaceutical compounds due to its unique structural properties and reactivity. It plays a significant role in the development of new drugs with potential therapeutic applications.
Used in Antimigraine Applications:
In the pharmaceutical industry, methyl D-prolinate is used as a key component in the synthesis of Eletriptan (E505000), which is an antimigraine drug. Eletriptan acts as a selective serotonin receptor agonist, providing relief from migraine symptoms by constricting blood vessels and reducing inflammation.

Check Digit Verification of cas no

The CAS Registry Mumber 43041-12-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,0,4 and 1 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 43041-12:
69 % 10 = 9
So 43041-12-9 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name (S)-methyl pyrrolidine-2-carboxylate

1.2 Other means of identification

Product number -
Other names Methyl D-prolinate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:43041-12-9 SDS

43041-12-9Relevant articles and documents

Tetrahydropyrido [3, 4-d] pyrimidine derivative and medical application thereof


Paragraph 0351-0359, (2021/03/06)

The invention relates to a compound as shown in a general formula (I) or a stereoisomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or eutectic crystal thereof, an intermediate and a preparation method thereof, and application of the compound in preparation of drugs for treating diseases related to KRas-G12C activity or expression quantity.

Transition Metal-Free N-Arylation of Amino Acid Esters with Diaryliodonium Salts

Kervefors, Gabriella,Kersting, Leonard,Olofsson, Berit

supporting information, p. 5790 - 5795 (2021/03/08)

A transition metal-free approach for the N-arylation of amino acid derivatives has been developed. Key to this method is the use of unsymmetric diaryliodonium salts with anisyl ligands, which proved important to obtain high chemoselectivity and yields. The scope includes the transfer of both electron deficient, electron rich and sterically hindered aryl groups with a variety of different functional groups. Furthermore, a cyclic diaryliodonium salt was successfully employed in the arylation. The N-arylated products were obtained with retained enantiomeric excess.

Discovery of γ-Lactam alkaloid derivatives as potential fungicidal agents targeting steroid biosynthesis

Cao, Xiufang,Huang, Daye,Huang, Wenbo,Ke, Shaoyong,Song, Di,Wang, Shuangshuang

, p. 14438 - 14451 (2020/12/23)

Biological control of plant pathogens is considered as one of the green and effective technologies using beneficial microorganisms or microbial secondary metabolites against plant diseases, and so microbial natural products have played important roles in the research and development of new and green agrochemicals. To explore the potential applications for natural γ-lactam alkaloids and their derivatives, 26 γ-lactams that have flexible substituent patterns were synthesized and characterized, and their in vitro antifungal activities against eight kinds of plant pathogens belonging to oomycetes, basidiomycetes, and deuteromycetes were fully evaluated. In addition, the high potential compounds were further tested using an in vivo assay against Phytophthora blight of pepper to verify a practical application for controlling oomycete diseases. The potential modes of action for compound D1 against Phytophthora capsici were also investigated using microscopic technology (optical microscopy, scanning electron microscopy, and transmission electron microscopy) and label-free quantitative proteomics analysis. The results demonstrated that compound D1 may be a potential novel fungicidal agent against oomycete diseases (EC50 = 4.9748 μg·mL-1 for P. capsici and EC50 = 5.1602 μg·mL-1 for Pythium aphanidermatum) that can act on steroid biosynthesis, which can provide a certain theoretical basis for the development of natural lactam derivatives as potential antifungal agents.

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