diethyl (1S,2S)-3-acetoxy-1-hydroxy-2-[(R)-1-phenylethylamino]propylphosphonate

Base Information

• Chemical Name: diethyl (1S,2S)-3-acetoxy-1-hydroxy-2-[(R)-1-phenylethylamino]propylphosphonate
• CAS No.: 1284299-35-9
• Molecular Formula: C₁₇H₂₈NO₆P
• Molecular Weight: 373.386
• Mol file: 1284299-35-9.mol

Synonyms:diethyl (1S,2S)-3-acetoxy-1-hydroxy-2-[(R)-1-phenylethylamino]propylphosphonate

Chemical Property of diethyl (1S,2S)-3-acetoxy-1-hydroxy-2-[(R)-1-phenylethylamino]propylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of diethyl (1S,2S)-3-acetoxy-1-hydroxy-2-[(R)-1-phenylethylamino]propylphosphonate

There total 1 articles about diethyl (1S,2S)-3-acetoxy-1-hydroxy-2-[(R)-1-phenylethylamino]propylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C15H24NO4P + acetic acid (64-19-7,77671-22-8) → diethyl (1S,2S)-3-acetoxy-1-hydroxy-2-[(R)-1-phenylethylamino]propylphosphonate (1284299-35-9)

Guidance literature:

In dichloromethane; for 9h; regioselective reaction; Reflux;

DOI:10.1016/j.tetasy.2011.01.005

Reference yield: 93.0%

diethyl (1S,2S)-3-acetoxy-1-hydroxy-2-[(R)-1-phenylethylamino]propylphosphonate (1284299-35-9) → diethyl (2R,3S)-3-acetoxymethyl-1-[(R)-1-phenylethyl]aziridin-2-yl-2-phosphonate (1284299-39-3)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at -70 - 20 ℃; stereospecific reaction; Inert atmosphere;

DOI:10.1016/j.tetasy.2011.01.005

upstream raw materials:

acetic acid

Downstream raw materials:

diethyl (2R,3S)-3-acetoxymethyl-1-[(R)-1-phenylethyl]aziridin-2-yl-2-phosphonate