3-fluoro-4-((3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)aniline

Base Information

Chemical Name:3-fluoro-4-((3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)aniline
CAS No.:949556-71-2
Molecular Formula:C₂₀H₁₆FIN₄O₂
Molecular Weight:490.276
Hs Code.:

Synonyms:3-fluoro-4-((3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)aniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-fluoro-4-((3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)aniline

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Technology Process of 3-fluoro-4-((3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)aniline

There total 5 articles about 3-fluoro-4-((3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 949556-70-1
4-(2-fluoro-4-nitrophenoxy)-3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine

: 949556-71-2
3-fluoro-4-((3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)aniline

Guidance literature:: With tin(II) chloride dihdyrate; In ethanol; at 65 ℃; for 1h; Inert atmosphere;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 949556-71-2
3-fluoro-4-((3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)aniline

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

2: trifluoroacetic acid / 18 h / 60 °C / Inert atmosphere

3: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 18 h

5: tin(II) chloride dihdyrate / ethanol / 1 h / 65 °C / Inert atmosphere

With tin(II) chloride dihdyrate; iodine; potassium carbonate; caesium carbonate; trifluoroacetic acid; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 949556-47-2
4-(2-fluoro-4-nitrophenoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine

: 949556-71-2
3-fluoro-4-((3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)aniline

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / 18 h / 60 °C / Inert atmosphere

2: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 18 h

4: tin(II) chloride dihdyrate / ethanol / 1 h / 65 °C / Inert atmosphere

With tin(II) chloride dihdyrate; iodine; potassium carbonate; trifluoroacetic acid; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;