dibenzyl (E)-2-(4-oxobut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate

Base Information

Chemical Name:dibenzyl (E)-2-(4-oxobut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate
CAS No.:1403649-26-2
Molecular Formula:C₂₆H₂₈O₆
Molecular Weight:436.505
Hs Code.:

Synonyms:dibenzyl (E)-2-(4-oxobut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dibenzyl (E)-2-(4-oxobut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate

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Technology Process of dibenzyl (E)-2-(4-oxobut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate

There total 5 articles about dibenzyl (E)-2-(4-oxobut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1403649-25-1
dibenzyl (E)-2-(4-hydroxybut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate

: 1403649-26-2
dibenzyl (E)-2-(4-oxobut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201204274

Reference yield:

: C₂₈H₃₂O₇

: 1403649-26-2
dibenzyl (E)-2-(4-oxobut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 1 h

2: Dess-Martin periodane / dichloromethane / 20 °C / Inert atmosphere

With potassium carbonate; Dess-Martin periodane; In methanol; dichloromethane;
DOI:10.1002/anie.201204274

Reference yield:

: 15014-25-2
malonic acid dibenzyl ester

: 1403649-26-2
dibenzyl (E)-2-(4-oxobut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; toluene / 0.5 h / 20 °C / Inert atmosphere

1.2: 100 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; toluene / 0.5 h / 20 °C / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

3.1: potassium carbonate / methanol / 1 h

4.1: Dess-Martin periodane / dichloromethane / 20 °C / Inert atmosphere

With sodium hydride; potassium carbonate; Dess-Martin periodane; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201204274