dibenzyl (E)-2-(4-hydroxybut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate

Base Information

• Chemical Name: dibenzyl (E)-2-(4-hydroxybut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate
• CAS No.: 1403649-25-1
• Molecular Formula: C₂₆H₃₀O₆
• Molecular Weight: 438.521
• Mol file: 1403649-25-1.mol

Synonyms:dibenzyl (E)-2-(4-hydroxybut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate

Chemical Property of dibenzyl (E)-2-(4-hydroxybut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzyl (E)-2-(4-hydroxybut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate

There total 3 articles about dibenzyl (E)-2-(4-hydroxybut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C28H32O7 → dibenzyl (E)-2-(4-hydroxybut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate (1403649-25-1)

Guidance literature:

With potassium carbonate; In methanol; for 1h;

DOI:10.1002/anie.201204274

Reference yield:

malonic acid dibenzyl ester (15014-25-2) → dibenzyl (E)-2-(4-hydroxybut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate (1403649-25-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; toluene / 0.5 h / 20 °C / Inert atmosphere

1.2: 100 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; toluene / 0.5 h / 20 °C / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

3.1: potassium carbonate / methanol / 1 h

With sodium hydride; potassium carbonate; In methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1002/anie.201204274

Reference yield:

dibenzyl 2-((tetrahydrofuran-2-yl)methyl)malonate (1134802-50-8) → dibenzyl (E)-2-(4-hydroxybut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate (1403649-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; toluene / 0.5 h / 20 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: potassium carbonate / methanol / 1 h

With sodium hydride; potassium carbonate; In methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1002/anie.201204274

upstream raw materials:

dibenzyl 2-((tetrahydrofuran-2-yl)methyl)malonate

malonic acid dibenzyl ester

Downstream raw materials:

C₃₀H₃₄O₇

C₃₀H₃₄O₇

dibenzyl (E)-2-(4-oxobut-2-enyl)-2-((tetrahydrofuran-2-yl)methyl)malonate