methyl 2-(1-isoquinolinyl)-3-methyl-5-hydroxy-5-phenyl-4,5-dihydro-3H-pyrrole 3-carboxylate

Base Information

• Chemical Name: methyl 2-(1-isoquinolinyl)-3-methyl-5-hydroxy-5-phenyl-4,5-dihydro-3H-pyrrole 3-carboxylate
• CAS No.: 111505-84-1
• Molecular Formula: C₂₂H₂₀N₂O₃
• Molecular Weight: 360.412

Synonyms:methyl 2-(1-isoquinolinyl)-3-methyl-5-hydroxy-5-phenyl-4,5-dihydro-3H-pyrrole 3-carboxylate

Chemical Property of methyl 2-(1-isoquinolinyl)-3-methyl-5-hydroxy-5-phenyl-4,5-dihydro-3H-pyrrole 3-carboxylate

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Technology Process of methyl 2-(1-isoquinolinyl)-3-methyl-5-hydroxy-5-phenyl-4,5-dihydro-3H-pyrrole 3-carboxylate

There total 3 articles about methyl 2-(1-isoquinolinyl)-3-methyl-5-hydroxy-5-phenyl-4,5-dihydro-3H-pyrrole 3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2-benzoyl-1,2-dihydroisoquinaldonitrile hydrofluoroborate + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → methyl 2-(1-isoquinolinyl)-3-methyl-5-hydroxy-5-phenyl-4,5-dihydro-3H-pyrrole 3-carboxylate (111505-84-1)

Guidance literature:

In N,N-dimethyl-formamide; at 0 ℃; for 1h; Mechanism; in the presence of triethylamine;

Reference yield: 50.0%

fluoroborate de 2-benzoyl-1,2-dihydroisoquinaldonitrile (68001-26-3) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → 2-(1-isoquinoleinyl)-3-methyl-5-hydroxy-5-phenyl-4,5-dihydro-3H-pyrrole-3-carboxylate de methyle (111505-84-1,129625-07-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 4h;

Reference yield:

2-(1-isoquinoleinyl)-3-methyl-5-hydroxy-5-phenyl-4,5-dihydro-3H-pyrrole-3-carboxylate de methyle (111505-84-1,129625-07-6) → (3R,5R)-5-Hydroxy-2-isoquinolin-1-yl-3-methyl-5-phenyl-4,5-dihydro-3H-pyrrole-3-carboxylic acid methyl ester (111505-84-1,129625-07-6)

Guidance literature:

With hydrogen cation; In chloroform-d1;

upstream raw materials:

2-(1-isoquinoleinyl)-3-methyl-5-hydroxy-5-phenyl-4,5-dihydro-3H-pyrrole-3-carboxylate de methyle

fluoroborate de 2-benzoyl-1,2-dihydroisoquinaldonitrile

methacrylic acid methyl ester

Downstream raw materials:

2-Isoquinolin-1-yl-3-methyl-5-phenyl-3H-pyrrole-3-carboxylic acid methyl ester

(3R,5R)-5-Hydroxy-2-isoquinolin-1-yl-3-methyl-5-phenyl-4,5-dihydro-3H-pyrrole-3-carboxylic acid methyl ester

1-(3-methyl-5-phenyl-pyrrol-2-yl)-isoquinoline

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