(S)-2-[N-Benzyloxycarbonyl-N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]aminomethyl]-5-cyano-1-(1-phenylethylcarbamoylmethyl)-benzimidazole

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Chemical Name:(S)-2-[N-Benzyloxycarbonyl-N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]aminomethyl]-5-cyano-1-(1-phenylethylcarbamoylmethyl)-benzimidazole
CAS No.:247132-62-3
Molecular Formula:C₄₃H₄₆N₆O₆
Molecular Weight:742.875
Hs Code.:

(S)-2-[N-Benzyloxycarbonyl-N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]aminomethyl]-5-cyano-1-(1-phenylethylcarbamoylmethyl)-benzimidazole

Synonyms:(S)-2-[N-Benzyloxycarbonyl-N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]aminomethyl]-5-cyano-1-(1-phenylethylcarbamoylmethyl)-benzimidazole

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Chemical Property of (S)-2-[N-Benzyloxycarbonyl-N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]aminomethyl]-5-cyano-1-(1-phenylethylcarbamoylmethyl)-benzimidazole

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Technology Process of (S)-2-[N-Benzyloxycarbonyl-N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]aminomethyl]-5-cyano-1-(1-phenylethylcarbamoylmethyl)-benzimidazole

There total 9 articles about (S)-2-[N-Benzyloxycarbonyl-N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]aminomethyl]-5-cyano-1-(1-phenylethylcarbamoylmethyl)-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 939-80-0
4-chloro-3-nitrobenzonitrile

: 247132-62-3
(S)-2-[N-Benzyloxycarbonyl-N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]aminomethyl]-5-cyano-1-(1-phenylethylcarbamoylmethyl)-benzimidazole

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / ethanol / 18 h / 20 - 50 °C

2: H₂ / Pd/C / tetrahydrofuran / 2 h / 20 °C / 760 Torr

3: 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / CHCl₃ / 3 h / 20 °C

4: AcOH / 96 h / 90 °C

5: aq. Na₂CO₃ / tetrahydrofuran / 12 h / 20 °C

6: EDC; HOBt / dimethylformamide / 15 h / 20 °C

With hydrogen; sodium carbonate; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.06.009

Reference yield:

: 138227-62-0
tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

: 247132-62-3
(S)-2-[N-Benzyloxycarbonyl-N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]aminomethyl]-5-cyano-1-(1-phenylethylcarbamoylmethyl)-benzimidazole

Guidance literature:: Multi-step reaction with 8 steps

1: H₂ / Pd/C / ethanol; tetrahydrofuran / 3 h / 20 °C / 2280 Torr

2: aq. NaHCO₃ / tetrahydrofuran / 1 h / 20 °C

3: NaH / dimethylformamide / 2 h / 20 °C

4: NaOH / tetrahydrofuran; ethanol / 1 h / 50 °C

5: 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / CHCl₃ / 3 h / 20 °C

6: AcOH / 96 h / 90 °C

7: aq. Na₂CO₃ / tetrahydrofuran / 12 h / 20 °C

8: EDC; HOBt / dimethylformamide / 15 h / 20 °C

With sodium hydroxide; hydrogen; sodium hydride; sodium hydrogencarbonate; sodium carbonate; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.06.009

Reference yield:

: 247132-58-7
N-(4-Cyano-2-nitrophenyl)glycine tert-butyl ester

: 247132-62-3
(S)-2-[N-Benzyloxycarbonyl-N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]aminomethyl]-5-cyano-1-(1-phenylethylcarbamoylmethyl)-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / tetrahydrofuran / 2 h / 20 °C / 760 Torr

2: 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / CHCl₃ / 3 h / 20 °C

3: AcOH / 96 h / 90 °C

4: aq. Na₂CO₃ / tetrahydrofuran / 12 h / 20 °C

5: EDC; HOBt / dimethylformamide / 15 h / 20 °C

With hydrogen; sodium carbonate; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; palladium on activated charcoal; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.06.009