6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-cyclopropylmethyl-nicotinamide

Base Information

• Chemical Name: 6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-cyclopropylmethyl-nicotinamide
• CAS No.: 1159600-49-3
• Molecular Formula: C₂₁H₂₀ClN₃O₃
• Molecular Weight: 397.861
• Mol file: 1159600-49-3.mol

Synonyms:6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-cyclopropylmethyl-nicotinamide

Chemical Property of 6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-cyclopropylmethyl-nicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-cyclopropylmethyl-nicotinamide

There total 12 articles about 6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-cyclopropylmethyl-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (1159600-45-9) + cyclopropanemethylamine (2516-47-4) → 6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-cyclopropylmethyl-nicotinamide (1159600-49-3)

Guidance literature:

cyclopropanemethylamine; With trimethylaluminum; In 1,4-dioxane; toluene; at 20 ℃; for 1h;

6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester; In 1,4-dioxane; toluene; at 85 - 95 ℃; for 1h;

Reference yield: 70.0%

→ 6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-cyclopropylmethyl-nicotinamide (1159600-49-3)

Guidance literature:

Reference yield:

3-fluorobenzaldehyde oxime (458-02-6,154238-36-5) → 6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-cyclopropylmethyl-nicotinamide (1159600-49-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 - 35 °C

2.1: triethylamine / diethyl ether / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C

5.1: trimethylaluminum / toluene; 1,4-dioxane / 1 h / 20 °C

5.2: 1 h / 85 - 95 °C

With N-chloro-succinimide; lithium aluminium tetrahydride; trimethylaluminum; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide; toluene; mineral oil;

upstream raw materials:

6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester

cyclopropanemethylamine

3-fluorobenzaldehyde oxime

N-hydroxy-3-fluoro-benzenecarboximidoyl chloride