(S)-methyl 3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoate

Base Information

Chemical Name:(S)-methyl 3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoate
CAS No.:1354894-20-4
Molecular Formula:C₁₈H₂₃N₃O₃
Molecular Weight:329.399
Hs Code.:

Synonyms:(S)-methyl 3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoate

Chemical Property:

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Technology Process of (S)-methyl 3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoate

There total 4 articles about (S)-methyl 3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2C₂HF₃O₂*C₇H₁₂N₂

: 40203-94-9
methyl (S)-2-isocyanato-3-phenylpropanoate

: 1354894-20-4
(S)-methyl 3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c1cc16178d

Reference yield:

: 199538-99-3
tert-butyl 4-(prop-2-yn-1-yl)piperazine-1-carboxylate

: 1354894-20-4
(S)-methyl 3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 0 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 0 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c1cc16178d

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1354894-20-4
(S)-methyl 3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 15 h / 0 - 50 °C / Inert atmosphere

2: sodium hydrogencarbonate / dichloromethane; water / 0.25 h / 0 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 0 °C / Inert atmosphere

With thionyl chloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c1cc16178d