(S)-3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoic acid hydrochloride

Base Information

Chemical Name:(S)-3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoic acid hydrochloride
CAS No.:1354894-21-5
Molecular Formula:C₁₇H₂₁N₃O₃*ClH
Molecular Weight:351.833
Hs Code.:

Synonyms:(S)-3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoic acid hydrochloride

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Chemical Property of (S)-3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoic acid hydrochloride

Chemical Property:

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Technology Process of (S)-3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoic acid hydrochloride

There total 6 articles about (S)-3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354894-20-4
(S)-methyl 3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoate

: 1354894-21-5
(S)-3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoic acid hydrochloride

Guidance literature:: (S)-methyl 3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoate; With water; In tetrahydrofuran; at 0 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 0 ℃; pH=2; Inert atmosphere;
DOI:10.1039/c1cc16178d

Reference yield:

: 199538-99-3
tert-butyl 4-(prop-2-yn-1-yl)piperazine-1-carboxylate

: 1354894-21-5
(S)-3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 0 °C / Inert atmosphere

3.1: water / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

3.2: 0 °C / pH 2 / Inert atmosphere

With water; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c1cc16178d

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1354894-21-5
(S)-3-phenyl-2-(4-(prop-2-yn-1-yl)piperazine-1-carboxamido)propanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 15 h / 0 - 50 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / dichloromethane; water / 0.25 h / 0 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 0 °C / Inert atmosphere

4.1: water / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

4.2: 0 °C / pH 2 / Inert atmosphere

With thionyl chloride; water; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/c1cc16178d