[5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone

Base Information

Chemical Name:[5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone
CAS No.:1293281-49-8
Molecular Formula:C₂₁H₂₂FN₇O
Molecular Weight:407.45
Hs Code.:

Synonyms:[5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone

Suppliers and Price of [5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
Seltorexant 99.51%
250mg
$ 2386.00

ChemScene
Seltorexant 99.51%
100mg
$ 1432.00

Chemenu
[2-(4,6-dimethylpyrimidin-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone 95%+
250mg
$ 4343.00

Chemenu
[2-(4,6-dimethylpyrimidin-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone 95%+
100mg
$ 2234.00

Total 35 raw suppliers

Chemical Property of [5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone

Chemical Property:

Purity/Quality:

99%min. ^*data from raw suppliers

Seltorexant 99.51% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone

There total 8 articles about [5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1293286-15-3
2-fluoro-6-(2Η-1,2,3-triazol-2-yl)benzoyl chloride

: 2-(4,6-dimethylpyrimidin-2-yl)octahydropyrrolo[3,4-c]pyrrole bis-HCI salt

: 1293281-49-8
[5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone

Guidance literature:: 2-(4,6-dimethylpyrimidin-2-yl)octahydropyrrolo[3,4-c]pyrrole bis-HCI salt; With sodium carbonate; In water; toluene; at 0 ℃; for 0.25h;

2-fluoro-6-(2Η-1,2,3-triazol-2-yl)benzoyl chloride; In water; toluene; at 0 - 70 ℃; for 2.5h;

Reference yield: 74.0%

: 1186050-58-7
2-fluoro-6-(2Η-1,2,3-triazol-2-yl)benzoic acid

: 1293284-71-5
2-(4,6-dimethyl-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole

: 1293281-49-8
[5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone

Guidance literature:: With thionyl chloride; sodium carbonate; sodium hydroxide; In water; toluene; at 0 - 50 ℃; for 4.5h; Inert atmosphere;

Reference yield:

: 186202-73-3
tert-butyl 5-benzylhexahydropyrrolo[3.4-c]pyrrole-2(1H)-carboxylate

: 1293281-49-8
[5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / acetic acid; methanol / 72 h / 3620.13 Torr

2: caesium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 23 °C

4: thionyl chloride; sodium hydroxide; sodium carbonate / toluene; water / 4.5 h / 0 - 50 °C / Inert atmosphere

With thionyl chloride; hydrogen; sodium carbonate; caesium carbonate; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene;