N(α)-[(1,1-dimethylethoxy)carbonyl]-N(?)-(8-phenyloctyl)-L-histidine methyl ester

Base Information

Chemical Name:N(α)-[(1,1-dimethylethoxy)carbonyl]-N(?)-(8-phenyloctyl)-L-histidine methyl ester
CAS No.:1334648-21-3
Molecular Formula:C₂₆H₃₉N₃O₄
Molecular Weight:457.613
Hs Code.:

Synonyms:N(α)-[(1,1-dimethylethoxy)carbonyl]-N(?)-(8-phenyloctyl)-L-histidine methyl ester

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Chemical Property of N(α)-[(1,1-dimethylethoxy)carbonyl]-N(?)-(8-phenyloctyl)-L-histidine methyl ester

Chemical Property:

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Technology Process of N(α)-[(1,1-dimethylethoxy)carbonyl]-N(?)-(8-phenyloctyl)-L-histidine methyl ester

There total 6 articles about N(α)-[(1,1-dimethylethoxy)carbonyl]-N(?)-(8-phenyloctyl)-L-histidine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 10472-97-6
8-phenyloctan-1-ol

: 20898-43-5,133467-03-5,165062-56-6
4-(2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-1H-imidazole-1-carboxylic acid tert-butyl ester

: 1334648-21-3
N(α)-[(1,1-dimethylethoxy)carbonyl]-N(?)-(8-phenyloctyl)-L-histidine methyl ester

Guidance literature:: With trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -75 - 20 ℃;

Reference yield:

: C₁₅H₂₁F₃O₃S

: 20898-43-5,133467-03-5,165062-56-6
4-(2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-1H-imidazole-1-carboxylic acid tert-butyl ester

: 1334648-21-3
N(α)-[(1,1-dimethylethoxy)carbonyl]-N(?)-(8-phenyloctyl)-L-histidine methyl ester

Guidance literature:: C₁₅H₂₁F₃O₃S; 4-(2-tert-butoxycarbonylamino-2-methoxycarbonyl-ethyl)-1H-imidazole-1-carboxylic acid tert-butyl ester; In dichloromethane; at -75 - 20 ℃; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water; for 0.5h;
DOI:10.1021/jo201599c

Reference yield:

: 4467-54-3,5619-10-3,7389-87-9,18684-16-7,22888-60-4,32381-17-2,92742-29-5,100009-20-9
histidine methyl ester hydrochloride

: 1334648-21-3
N(α)-[(1,1-dimethylethoxy)carbonyl]-N(?)-(8-phenyloctyl)-L-histidine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / methanol / 48.5 h / 20 °C

2.1: dichloromethane / -75 - 20 °C / Inert atmosphere

2.2: 0.5 h

With triethylamine; In methanol; dichloromethane;
DOI:10.1021/jo201599c