3-Methyl-2-[2'-(methylsulfonyl)biphenyl-4-yl]-5-(trifluoromethyl)quinoxaline

Base Information

• Chemical Name: 3-Methyl-2-[2'-(methylsulfonyl)biphenyl-4-yl]-5-(trifluoromethyl)quinoxaline
• CAS No.: 1221265-39-9
• Molecular Formula: C₂₃H₁₇F₃N₂O₂S
• Molecular Weight: 442.461
• Mol file: 1221265-39-9.mol

Synonyms:3-methyl-2-[2'-(methylsulfonyl)-1,1'-biphenyl-4-yl]-5-(trifluoromethyl)-quinoxaline

Chemical Property of 3-Methyl-2-[2'-(methylsulfonyl)biphenyl-4-yl]-5-(trifluoromethyl)quinoxaline

Chemical Property:

• Density: 1.332

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Wye 672 is a tissue selective liver X-receptor agonist.

Technology Process of 3-Methyl-2-[2'-(methylsulfonyl)biphenyl-4-yl]-5-(trifluoromethyl)quinoxaline

There total 2 articles about 3-Methyl-2-[2'-(methylsulfonyl)biphenyl-4-yl]-5-(trifluoromethyl)quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-[3-methyl-5-(trifluoromethyl)quinoxalin-2-yl]phenyl trifluoromethanesulfonate (1221265-53-7) + (2-(methylsulfonyl)-phenyl)boronic acid → 3-methyl-2-[2'-(methylsulfonyl)-1,1'-biphenyl-4-yl]-5-(trifluoromethyl)-quinoxaline (1221265-39-9)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 1h;

DOI:10.1021/jm100034x

Reference yield:

→ 3-methyl-2-[2'-(methylsulfonyl)-1,1'-biphenyl-4-yl]-5-(trifluoromethyl)-quinoxaline (1221265-39-9)

Guidance literature:

upstream raw materials:

4-[3-methyl-5-(trifluoromethyl)quinoxalin-2-yl]phenyl trifluoromethanesulfonate