4-[3-methyl-5-(trifluoromethyl)quinoxalin-2-yl]phenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 4-[3-methyl-5-(trifluoromethyl)quinoxalin-2-yl]phenyl trifluoromethanesulfonate
• CAS No.: 1221265-53-7
• Molecular Formula: C₁₇H₁₀F₆N₂O₃S
• Molecular Weight: 436.334
• Mol file: 1221265-53-7.mol

Synonyms:4-[3-methyl-5-(trifluoromethyl)quinoxalin-2-yl]phenyl trifluoromethanesulfonate

Chemical Property of 4-[3-methyl-5-(trifluoromethyl)quinoxalin-2-yl]phenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-[3-methyl-5-(trifluoromethyl)quinoxalin-2-yl]phenyl trifluoromethanesulfonate

There total 1 articles about 4-[3-methyl-5-(trifluoromethyl)quinoxalin-2-yl]phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + 4-[3-methyl-5-(trifluoromethyl)-quinoxalin-2-yl]phenol (1221265-52-6) → 4-[3-methyl-5-(trifluoromethyl)quinoxalin-2-yl]phenyl trifluoromethanesulfonate (1221265-53-7)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃;

Reference yield: 63.0%

4-[3-methyl-5-(trifluoromethyl)quinoxalin-2-yl]phenyl trifluoromethanesulfonate (1221265-53-7) + (2-(methylsulfonyl)-phenyl)boronic acid → 3-methyl-2-[2'-(methylsulfonyl)-1,1'-biphenyl-4-yl]-5-(trifluoromethyl)-quinoxaline (1221265-39-9)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 1h;

DOI:10.1021/jm100034x

Reference yield: 48.0%

4-[3-methyl-5-(trifluoromethyl)quinoxalin-2-yl]phenyl trifluoromethanesulfonate (1221265-53-7) + 3-(methanesulfonyl)phenylboronic acid (373384-18-0) → WYE-672 (1221265-37-7)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 1h;

upstream raw materials:

N,N-phenylbistrifluoromethane-sulfonimide

4-[3-methyl-5-(trifluoromethyl)-quinoxalin-2-yl]phenol

Downstream raw materials:

WYE-672

3-methyl-2-[2'-(methylsulfonyl)-1,1'-biphenyl-4-yl]-5-(trifluoromethyl)-quinoxaline

3-methyl-2-[4'-(methylsulfonyl)-1,1'-biphenyl-4-yl]-5-(trifluoromethyl)-quinoxaline