methyl 3-(4-(methylsulfonyl)piperazin-1-yl)-2-phenylquinoxaline-6-carboxylate

Base Information

Chemical Name:methyl 3-(4-(methylsulfonyl)piperazin-1-yl)-2-phenylquinoxaline-6-carboxylate
CAS No.:1268865-87-7
Molecular Formula:C₂₁H₂₂N₄O₄S
Molecular Weight:426.496
Hs Code.:

Synonyms:methyl 3-(4-(methylsulfonyl)piperazin-1-yl)-2-phenylquinoxaline-6-carboxylate

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Chemical Property of methyl 3-(4-(methylsulfonyl)piperazin-1-yl)-2-phenylquinoxaline-6-carboxylate

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Technology Process of methyl 3-(4-(methylsulfonyl)piperazin-1-yl)-2-phenylquinoxaline-6-carboxylate

There total 7 articles about methyl 3-(4-(methylsulfonyl)piperazin-1-yl)-2-phenylquinoxaline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1268865-21-9
methyl 2-phenyl-3-(piperazin-1-yl)quinoxaline-6-carboxylate

: 124-63-0
methanesulfonyl chloride

: 1268865-87-7
methyl 3-(4-(methylsulfonyl)piperazin-1-yl)-2-phenylquinoxaline-6-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1268865-87-7
methyl 3-(4-(methylsulfonyl)piperazin-1-yl)-2-phenylquinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 °C

2.1: ammonium chloride; iron / water; methanol / 5 h / Reflux

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 20 °C

4.1: phosphorus(V) oxybromide / acetonitrile / Reflux

4.2: pH 7 - 8

5.1: dimethyl sulfoxide / 3 h / 125 °C / Sealed tube

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; phosphorus(V) oxybromide; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1268865-87-7
methyl 3-(4-(methylsulfonyl)piperazin-1-yl)-2-phenylquinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 3 h / 0 °C / Reflux

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 °C

3.1: ammonium chloride; iron / water; methanol / 5 h / Reflux

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 20 °C

5.1: phosphorus(V) oxybromide / acetonitrile / Reflux

5.2: pH 7 - 8

6.1: dimethyl sulfoxide / 3 h / 125 °C / Sealed tube

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With thionyl chloride; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; phosphorus(V) oxybromide; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;