trans-3a,4-dihydro-6-(4-methoxyphenyl)-3H,6H-furo<3,4-c>isoxazole

Base Information

• Chemical Name: trans-3a,4-dihydro-6-(4-methoxyphenyl)-3H,6H-furo<3,4-c>isoxazole
• CAS No.: 132439-91-9
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.24
• Mol file: 132439-91-9.mol

Synonyms:trans-3a,4-dihydro-6-(4-methoxyphenyl)-3H,6H-furo<3,4-c>isoxazole

Chemical Property of trans-3a,4-dihydro-6-(4-methoxyphenyl)-3H,6H-furo<3,4-c>isoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-3a,4-dihydro-6-(4-methoxyphenyl)-3H,6H-furo<3,4-c>isoxazole

There total 4 articles about trans-3a,4-dihydro-6-(4-methoxyphenyl)-3H,6H-furo<3,4-c>isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-1-methoxy-4-(2-nitrovinyl)benzene (3179-10-0,5576-97-6) + allyl alcohol (107-18-6) → 1-(allyloxy)-1-(4-methoxyphenyl)-2-nitroethane (132439-81-7) + trans-3a,4-dihydro-6-(4-methoxyphenyl)-3H,6H-furo<3,4-c>isoxazole (132439-91-9)

Guidance literature:

(E)-1-methoxy-4-(2-nitrovinyl)benzene; allyl alcohol; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃;

With dmap; triethylamine; methyl chloroformate; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(99)00741-3

Reference yield:

(E)-1-methoxy-4-(2-nitrovinyl)benzene (3179-10-0,5576-97-6) + allyl alcohol (107-18-6) → trans-3a,4-dihydro-6-(4-methoxyphenyl)-3H,6H-furo<3,4-c>isoxazole (132439-91-9)

Guidance literature:

(E)-1-methoxy-4-(2-nitrovinyl)benzene; allyl alcohol; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃;

With dmap; triethylamine; methyl chloroformate; In tetrahydrofuran; for 1.5h; Heating;

DOI:10.1016/S0040-4020(99)00741-3

Reference yield:

1-methoxy-4-(2-nitro-vinyl)-benzene (3179-10-0) → trans-3a,4-dihydro-6-(4-methoxyphenyl)-3H,6H-furo<3,4-c>isoxazole (132439-91-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) potassium tert-butoxide / 1.) THF, -10 to -20 deg C, 2.) 15 min

2: trimethylamine, phenyl isocyanate / benzene / 48 h / Ambient temperature

With potassium tert-butylate; phenyl isocyanate; trimethylamine; In benzene;

upstream raw materials:

1-(allyloxy)-1-(4-methoxyphenyl)-2-nitroethane

(E)-1-methoxy-4-(2-nitrovinyl)benzene

allyl alcohol

1-methoxy-4-(2-nitro-vinyl)-benzene