(7S)-7-[(1R)-1-(4-methoxyphenyl)-2-nitroethyl]-1,4-dioxaspiro[4.5]decan-8-one

Base Information

Chemical Name:(7S)-7-[(1R)-1-(4-methoxyphenyl)-2-nitroethyl]-1,4-dioxaspiro[4.5]decan-8-one
CAS No.:1301743-46-3
Molecular Formula:C₁₇H₂₁NO₆
Molecular Weight:335.357
Hs Code.:

Synonyms:(7S)-7-[(1R)-1-(4-methoxyphenyl)-2-nitroethyl]-1,4-dioxaspiro[4.5]decan-8-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (7S)-7-[(1R)-1-(4-methoxyphenyl)-2-nitroethyl]-1,4-dioxaspiro[4.5]decan-8-one

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Technology Process of (7S)-7-[(1R)-1-(4-methoxyphenyl)-2-nitroethyl]-1,4-dioxaspiro[4.5]decan-8-one

There total 1 articles about (7S)-7-[(1R)-1-(4-methoxyphenyl)-2-nitroethyl]-1,4-dioxaspiro[4.5]decan-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 4746-97-8
cyclohexanedione monoethylene ketal

: 3179-10-0
1-methoxy-4-(2-nitro-vinyl)-benzene

: 1301743-46-3
(7S)-7-[(1R)-1-(4-methoxyphenyl)-2-nitroethyl]-1,4-dioxaspiro[4.5]decan-8-one

Guidance literature:: With N¹,N¹-dimethyl-N²-(((S)-pyrrolidin-2-yl)methyl)ethane-1,2-diamine; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 20 ℃; for 48h; optical yield given as %ee; stereoselective reaction;
DOI:10.1002/ejoc.201100125

Reference yield:

: 1301743-46-3
(7S)-7-[(1R)-1-(4-methoxyphenyl)-2-nitroethyl]-1,4-dioxaspiro[4.5]decan-8-one

: 1394131-95-3
3-(2-((2S,3R)-2-hydroxy-3-(4-methoxyphenyl)-4-nitrobutyl)-1,3-dioxolan-2-yl)propyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: disodium phosphate heptahydrate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Inert atmosphere

3: collidine / dichloromethane / 4 h / -78 °C / Inert atmosphere

With sodium tetrahydroborate; disodium phosphate heptahydrate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; 1: Baeyer-Villiger oxidation;
DOI:10.1039/c2ob25689d

Reference yield:

: 1301743-46-3
(7S)-7-[(1R)-1-(4-methoxyphenyl)-2-nitroethyl]-1,4-dioxaspiro[4.5]decan-8-one

: 1394131-96-4
(6S,7R)-6-hydroxy-7-(4-methoxyphenyl)-8-nitro-4-oxooctyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: disodium phosphate heptahydrate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Inert atmosphere

3: collidine / dichloromethane / 4 h / -78 °C / Inert atmosphere

4: iodine / acetone / 1 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; disodium phosphate heptahydrate; iodine; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; acetone; 1: Baeyer-Villiger oxidation;
DOI:10.1039/c2ob25689d