ethyl 3-(2-((chloro(((S)-1-ethoxy-1-oxopropan-2-yl)amino)-phosphoryl)oxy)phenyl)propanoate

Base Information

• Chemical Name: ethyl 3-(2-((chloro(((S)-1-ethoxy-1-oxopropan-2-yl)amino)-phosphoryl)oxy)phenyl)propanoate
• CAS No.: 1412427-04-3
• Molecular Formula: C₁₆H₂₃ClNO₆P
• Molecular Weight: 391.788
• Mol file: 1412427-04-3.mol

Synonyms:ethyl 3-(2-((chloro(((S)-1-ethoxy-1-oxopropan-2-yl)amino)-phosphoryl)oxy)phenyl)propanoate

Chemical Property of ethyl 3-(2-((chloro(((S)-1-ethoxy-1-oxopropan-2-yl)amino)-phosphoryl)oxy)phenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(2-((chloro(((S)-1-ethoxy-1-oxopropan-2-yl)amino)-phosphoryl)oxy)phenyl)propanoate

There total 3 articles about ethyl 3-(2-((chloro(((S)-1-ethoxy-1-oxopropan-2-yl)amino)-phosphoryl)oxy)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-(2-hydroxyphenyl)propanoate (20921-04-4) → ethyl 3-(2-((chloro(((S)-1-ethoxy-1-oxopropan-2-yl)amino)-phosphoryl)oxy)phenyl)propanoate (1412427-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; trichlorophosphate / diethyl ether / 18 h / -78 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 18 h / -78 - 20 °C / Inert atmosphere

With triethylamine; trichlorophosphate; In diethyl ether; dichloromethane;

Reference yield:

C11H13Cl2O4P (1422526-27-9) + (S)-alanine ethyl ester hydrochloride (1115-59-9) → ethyl 3-(2-((chloro(((S)-1-ethoxy-1-oxopropan-2-yl)amino)-phosphoryl)oxy)phenyl)propanoate (1412427-04-3)

Guidance literature:

With triethylamine; In dichloromethane; at -78 - 20 ℃; for 18h; Inert atmosphere;

Reference yield:

C6H4(CH2CH2C(O)O) (119-84-6,1341-36-2) → ethyl 3-(2-((chloro(((S)-1-ethoxy-1-oxopropan-2-yl)amino)-phosphoryl)oxy)phenyl)propanoate (1412427-04-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / 12 h / 0 °C / Inert atmosphere

1.2: pH 6 - 6.5

2.1: triethylamine; trichlorophosphate / diethyl ether / 18 h / -78 - 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 18 h / -78 - 20 °C / Inert atmosphere

With sulfuric acid; triethylamine; trichlorophosphate; In diethyl ether; dichloromethane;

upstream raw materials:

C₆H₄(CH₂CH₂C(O)O)

C₁₁H₁₃Cl₂O₄P

(S)-alanine ethyl ester hydrochloride

ethyl 3-(2-hydroxyphenyl)propanoate

Downstream raw materials:

ethyl 3-(2-(((R)-(((2R,3R,4R,5R)-5-(2,6-diamino-9H-pu r in-9-y l )-3, 4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(((S)-1-ethoxy-1-oxopropan-2-yl)amino)phosphoryl)oxy)phenyl)propanoate

ethyl 3-(2-(((S)-(((2R,3R,4R,5R)-5-(2-amino-6-(((benzyloxy)carbonyl)amino)-9H-purin-9-yl)-3-(((benzyloxy)carbonyl)oxy)-4-fluoro-4-methyltetrahydrofuran-2-yl)methoxy)(((S)-1-ethoxy-1-oxopropan-2-yl)amino)phosphoryl)oxy)phenyl)propanoate

ethyl 3-(2-(((S)-(((2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetra-hydrofuran-2-yl)methoxy)(((S)-1-ethoxy-1-oxopropan-2-yl)amino)phosphoryl)oxy)phenyl) propanoate