ethyl 3-(2-(((S)-(((2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetra-hydrofuran-2-yl)methoxy)(((S)-1-ethoxy-1-oxopropan-2-yl)amino)phosphoryl)oxy)phenyl) propanoate

Base Information

Chemical Name:ethyl 3-(2-(((S)-(((2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetra-hydrofuran-2-yl)methoxy)(((S)-1-ethoxy-1-oxopropan-2-yl)amino)phosphoryl)oxy)phenyl) propanoate
CAS No.:1412427-50-9
Molecular Formula:C₂₇H₃₇FN₇O₉P
Molecular Weight:653.604
Hs Code.:

ethyl 3-(2-(((S)-(((2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetra-hydrofuran-2-yl)methoxy)(((S)-1-ethoxy-1-oxopropan-2-yl)amino)phosphoryl)oxy)phenyl) propanoate

Synonyms:ethyl 3-(2-(((S)-(((2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetra-hydrofuran-2-yl)methoxy)(((S)-1-ethoxy-1-oxopropan-2-yl)amino)phosphoryl)oxy)phenyl) propanoate

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Chemical Property of ethyl 3-(2-(((S)-(((2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetra-hydrofuran-2-yl)methoxy)(((S)-1-ethoxy-1-oxopropan-2-yl)amino)phosphoryl)oxy)phenyl) propanoate

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Technology Process of ethyl 3-(2-(((S)-(((2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetra-hydrofuran-2-yl)methoxy)(((S)-1-ethoxy-1-oxopropan-2-yl)amino)phosphoryl)oxy)phenyl) propanoate

There total 8 articles about ethyl 3-(2-(((S)-(((2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetra-hydrofuran-2-yl)methoxy)(((S)-1-ethoxy-1-oxopropan-2-yl)amino)phosphoryl)oxy)phenyl) propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1412427-29-2
ethyl 3-(2-(((S)-(((2R,3R,4R,5R)-5-(2-amino-6-(((benzyloxy)carbonyl)amino)-9H-purin-9-yl)-3-(((benzyloxy)carbonyl)oxy)-4-fluoro-4-methyltetrahydrofuran-2-yl)methoxy)(((S)-1-ethoxy-1-oxopropan-2-yl)amino)phosphoryl)oxy)phenyl)propanoate

: 1412427-50-9
ethyl 3-(2-(((S)-(((2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetra-hydrofuran-2-yl)methoxy)(((S)-1-ethoxy-1-oxopropan-2-yl)amino)phosphoryl)oxy)phenyl) propanoate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; Inert atmosphere;

Reference yield:

: 20921-04-4
ethyl 3-(2-hydroxyphenyl)propanoate

: 1412427-50-9
ethyl 3-(2-(((S)-(((2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetra-hydrofuran-2-yl)methoxy)(((S)-1-ethoxy-1-oxopropan-2-yl)amino)phosphoryl)oxy)phenyl) propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; trichlorophosphate / diethyl ether / 18 h / -78 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 18 h / -78 - 20 °C / Inert atmosphere

3: 1-methyl-1H-imidazole / tetrahydrofuran / 0 - 20 °C

4: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

With 1-methyl-1H-imidazole; hydrogen; triethylamine; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;

Reference yield:

: ((2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol)

: 1412427-50-9
ethyl 3-(2-(((S)-(((2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetra-hydrofuran-2-yl)methoxy)(((S)-1-ethoxy-1-oxopropan-2-yl)amino)phosphoryl)oxy)phenyl) propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine

2: dmap / dichloromethane / 20 °C

3: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 24 h / 20 °C

4: 1-methyl-1H-imidazole / tetrahydrofuran / 0 - 20 °C

5: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

With pyridine; 1-methyl-1H-imidazole; hydrogen; triethylamine tris(hydrogen fluoride); dmap; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;