methyl (E)-5-((N-(but-2-yn-1-yl)-4-methylphenyl)sulfonamid)pent-2-enoate

Base Information

Chemical Name:methyl (E)-5-((N-(but-2-yn-1-yl)-4-methylphenyl)sulfonamid)pent-2-enoate
CAS No.:908000-28-2
Molecular Formula:C₁₇H₂₁NO₄S
Molecular Weight:335.424
Hs Code.:

Synonyms:methyl (E)-5-((N-(but-2-yn-1-yl)-4-methylphenyl)sulfonamid)pent-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (E)-5-((N-(but-2-yn-1-yl)-4-methylphenyl)sulfonamid)pent-2-enoate

Chemical Property:

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Technology Process of methyl (E)-5-((N-(but-2-yn-1-yl)-4-methylphenyl)sulfonamid)pent-2-enoate

There total 7 articles about methyl (E)-5-((N-(but-2-yn-1-yl)-4-methylphenyl)sulfonamid)pent-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: (E)-5-(toluene-4-sulfonylamino)pent-2-enoic acid methyl ester

: 3355-28-0
1-Bromo-2-butyne

: 908000-28-2
methyl (E)-5-((N-(but-2-yn-1-yl)-4-methylphenyl)sulfonamid)pent-2-enoate

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acs.orglett.5b00493

Reference yield:

: 718633-51-3
N-1-(3-oxopropyl)-4-methyl-1-benzenesulfonamide

: 908000-28-2
methyl (E)-5-((N-(but-2-yn-1-yl)-4-methylphenyl)sulfonamid)pent-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / acetonitrile / 24 h / 0 - 20 °C / Inert atmosphere

2: sodium iodide; potassium carbonate / acetonitrile / 3 h / 80 °C / Inert atmosphere

With potassium carbonate; sodium iodide; lithium hydroxide; In acetonitrile;
DOI:10.1021/acs.orglett.5b00493

Reference yield:

: 13379-98-1
3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol

: 908000-28-2
methyl (E)-5-((N-(but-2-yn-1-yl)-4-methylphenyl)sulfonamid)pent-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2: lithium hydroxide / acetonitrile / 24 h / 0 - 20 °C / Inert atmosphere

3: sodium iodide; potassium carbonate / acetonitrile / 3 h / 80 °C / Inert atmosphere

With potassium carbonate; Dess-Martin periodane; sodium iodide; lithium hydroxide; In dichloromethane; acetonitrile;
DOI:10.1021/acs.orglett.5b00493