718633-51-3

Basic information

• Product Name: Benzenesulfonamide, 4-methyl-N-(3-oxopropyl)-
• CAS NO: 718633-51-3
• Molecular Formula: C10H13NO3S
• Molecular Weight: 227.284
• Mol File: 718633-51-3.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 4-methyl-N-(3-oxopropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 4-methyl-N-(3-oxopropyl)-(718633-51-3)
• EPA Substance Registry System: Benzenesulfonamide, 4-methyl-N-(3-oxopropyl)-(718633-51-3)

Safety Data

• Hazardous Substances Data: 718633-51-3(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 41365-75-7 aminopropane diethyl acetal 
• 50487-71-3 4-methyl-N-(2-propenyl)benzenesulfonamide 
• 164532-58-5 N-(p-tosyl)-3-aminopropionaldehyde diethyl acetal 
• 107-02-8 acrolein 
• 59724-53-7 (±)-N-(2-hydroxypropyl)-4-methylbenzenesulfonamide 
• 13379-98-1 3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol 

Downstream Products

• 1385877-85-9 (3R,5R)-5-phenyl-1-tosylpyrrolidine-3-carbaldehyde 
• 1385877-86-0 (3R,5S)-5-phenyl-1-tosylpyrrolidine-3-carbaldehyde 
• 42908-33-8 3-{[(4-methylphenyl)sulfonyl]amino}propanoic acid 

Relevant articles and documents

Phosphine-Catalyzed Synthesis of Chiral N-Heterocycles through (Asymmetric) P(III)/P(V) Redox Cycling

Phosphine-catalyzed tandem Michael addition/intramolecular Wittig reactions have been developed for the synthesis of chiral 2,5-dihydro-1H-pyrrole and tetrahydropyridine derivatives. These processes have been rendered catalytic in phosphine, thanks to the in situ reduction of phosphine oxide by phenylsilane. Furthermore, catalytic and asymmetric P(III)/P(V) processes were implemented using enantiopure chiral phosphines.

Chemo- And diastereoselective synthesis of pyrrolidines from aroylformates and δ-tosylamino enones via P(NMe2)3-mediated reductive amination/base-catalyzed michael addition cascade

A novel P(NMe2)3-mediated tandem (1 + 4) annulation between aroylformates and δ-tosylamino enones has been developed that affords a facile synthesis of functionalized pyrrolidines in moderate to excellent yields with exclusive chemoselectivity and high diastereoselectivity. Mechanistic investigation reveals that the reaction proceeds through an unprecedented P(NMe2)3-mediated reductive amination/base-catalyzed Michael addition cascade. The reaction herein also represents the first study of the reactivity patterns of the Kukhtin-Ramirez adducts toward ambiphilic nucleophile-electrophiles.

Organocatalyzed Aerobic Oxidation of Aldehydes to Acids

The first example organocatalyzed aerobic oxidation of aldehydes to carboxylic acids in both organic solvent and water under mild conditions is developed. As low as 5 mol % N-hydroxyphthalimide was used as the organocatalyst, and molecular O2 was used as the sole oxidant. No transition metals or hazardous oxidants or cocatalysts were involved. A wide range of carboxylic acids bearing diverse functional groups were obtained from aldehydes, even from alcohols, in high yields.