3-{(2R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid tromethamine salt

Base Information

Chemical Name:3-{(2R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid tromethamine salt
CAS No.:1198180-64-1
Molecular Formula:C₄H₁₁NO₃*C₁₅H₁₄F₆O₃
Molecular Weight:477.401
Hs Code.:

Synonyms:3-{(2R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid tromethamine salt

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Chemical Property of 3-{(2R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid tromethamine salt

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Technology Process of 3-{(2R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid tromethamine salt

There total 7 articles about 3-{(2R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid tromethamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1198180-23-2
3-{(2R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 1198180-64-1
3-{(2R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid tromethamine salt

Guidance literature:: In methanol; water; at 20 ℃; for 2h;

Reference yield:

: 1899-24-7
5-bromo-2-furancarboxaldehyde

: 1198180-64-1
3-{(2R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid tromethamine salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 24 h / 95 - 110 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 48 h / 20 °C / 760.05 Torr

4.1: ethanol; lithium hydroxide / 4 h / 20 °C

4.2: pH 3

5.1: CHIRALPAK AS 50 mm IDx₅₀₀ mmL; solvent / hexane; ethanol; acetic acid / 30 °C / Resolution of racemate

6.1: water; methanol / 2 h / 20 °C

With ethanol; hydrogen; sodium hydride; sodium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; hexane; water; acetic acid; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 50527-72-5
3-(5-bromo-furan-2-yl)-acrylic acid ethyl ester

: 1198180-64-1
3-{(2R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid tromethamine salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 24 h / 95 - 110 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 48 h / 20 °C / 760.05 Torr

3.1: ethanol; lithium hydroxide / 4 h / 20 °C

3.2: pH 3

4.1: CHIRALPAK AS 50 mm IDx₅₀₀ mmL; solvent / hexane; ethanol; acetic acid / 30 °C / Resolution of racemate

5.1: water; methanol / 2 h / 20 °C

With ethanol; hydrogen; sodium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; hexane; water; acetic acid;