(E)-3-[3-(4-Phenyl-[1,2,3 ]triazol-1-ylmethyl)-phenyl]-acrylic acid methyl ester

Base Information

Chemical Name:(E)-3-[3-(4-Phenyl-[1,2,3 ]triazol-1-ylmethyl)-phenyl]-acrylic acid methyl ester
CAS No.:1267502-79-3
Molecular Formula:C₁₉H₁₇N₃O₂
Molecular Weight:319.363
Hs Code.:

Synonyms:(E)-3-[3-(4-Phenyl-[1,2,3 ]triazol-1-ylmethyl)-phenyl]-acrylic acid methyl ester

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Chemical Property of (E)-3-[3-(4-Phenyl-[1,2,3 ]triazol-1-ylmethyl)-phenyl]-acrylic acid methyl ester

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Technology Process of (E)-3-[3-(4-Phenyl-[1,2,3 ]triazol-1-ylmethyl)-phenyl]-acrylic acid methyl ester

There total 6 articles about (E)-3-[3-(4-Phenyl-[1,2,3 ]triazol-1-ylmethyl)-phenyl]-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99-04-7
m-Toluic acid

: 1267502-79-3
(E)-3-[3-(4-Phenyl-[1,2,3 ]triazol-1-ylmethyl)-phenyl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 25 °C / Reflux

2.1: thionyl chloride / 1 h / 25 °C / Reflux

3.1: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide; sodium L-ascorbate / N,N-dimethyl-formamide / 12 h / 25 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

6.1: sodium acetate; pyridinium chlorochromate / dichloromethane / 2 h / 25 °C

7.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 0 °C

7.2: 0.75 h / Cooling with ice

With N-Bromosuccinimide; copper(l) iodide; lithium aluminium tetrahydride; thionyl chloride; sodium azide; potassium tert-butylate; sodium acetate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1267502-76-0
3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-benzoic acid methyl ester

: 1267502-79-3
(E)-3-[3-(4-Phenyl-[1,2,3 ]triazol-1-ylmethyl)-phenyl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

2.1: sodium acetate; pyridinium chlorochromate / dichloromethane / 2 h / 25 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 0 °C

3.2: 0.75 h / Cooling with ice

With lithium aluminium tetrahydride; potassium tert-butylate; sodium acetate; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1267502-77-1
[3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-phenyl]-methanol

: 1267502-79-3
(E)-3-[3-(4-Phenyl-[1,2,3 ]triazol-1-ylmethyl)-phenyl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium acetate; pyridinium chlorochromate / dichloromethane / 2 h / 25 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 0 °C

2.2: 0.75 h / Cooling with ice

With potassium tert-butylate; sodium acetate; pyridinium chlorochromate; In dichloromethane; N,N-dimethyl-formamide;