(E)-N-hydroxy-3-[3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-phenyl]-acrylamide

Base Information

Chemical Name:(E)-N-hydroxy-3-[3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-phenyl]-acrylamide
CAS No.:1267502-48-6
Molecular Formula:C₁₈H₁₆N₄O₂
Molecular Weight:320.351
Hs Code.:

Synonyms:(E)-N-hydroxy-3-[3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-phenyl]-acrylamide

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Chemical Property of (E)-N-hydroxy-3-[3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-phenyl]-acrylamide

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Technology Process of (E)-N-hydroxy-3-[3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-phenyl]-acrylamide

There total 8 articles about (E)-N-hydroxy-3-[3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-phenyl]-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1267502-79-3
(E)-3-[3-(4-Phenyl-[1,2,3 ]triazol-1-ylmethyl)-phenyl]-acrylic acid methyl ester

: 1267502-48-6
(E)-N-hydroxy-3-[3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-phenyl]-acrylamide

Guidance literature:: With hydroxylamine hydrochloride; sodium methylate; In methanol; dichloromethane; at -20 - 25 ℃; for 3h;

Reference yield:

: 99-04-7
m-Toluic acid

: 1267502-48-6
(E)-N-hydroxy-3-[3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-phenyl]-acrylamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 25 °C / Reflux

2.1: thionyl chloride / 1 h / 25 °C / Reflux

3.1: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine; copper(l) iodide; sodium L-ascorbate / N,N-dimethyl-formamide / 12 h / 25 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

6.1: sodium acetate; pyridinium chlorochromate / dichloromethane / 2 h / 25 °C

7.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 0 °C

7.2: 0.75 h / Cooling with ice

8.1: hydroxylamine hydrochloride; sodium methylate / dichloromethane; methanol / -20 - 25 °C

With N-Bromosuccinimide; copper(l) iodide; lithium aluminium tetrahydride; thionyl chloride; sodium azide; hydroxylamine hydrochloride; potassium tert-butylate; sodium methylate; sodium acetate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1267502-76-0
3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-benzoic acid methyl ester

: 1267502-48-6
(E)-N-hydroxy-3-[3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-phenyl]-acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

2.1: sodium acetate; pyridinium chlorochromate / dichloromethane / 2 h / 25 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 0 °C

3.2: 0.75 h / Cooling with ice

4.1: hydroxylamine hydrochloride; sodium methylate / dichloromethane; methanol / -20 - 25 °C

With lithium aluminium tetrahydride; hydroxylamine hydrochloride; potassium tert-butylate; sodium methylate; sodium acetate; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;