(S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester

Base Information

Chemical Name:(S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester
CAS No.:142103-49-9
Molecular Formula:C₂₇H₃₁N₃O₆S
Molecular Weight:525.626
Hs Code.:

Synonyms:(S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester

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Technology Process of (S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester

There total 1 articles about (S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132286-82-9
(S)-4-(2-Amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester

: 501-53-1,94274-21-2
benzyl chloroformate

: 142103-49-9
(S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; Ambient temperature;
DOI:10.1021/jm00092a006

Reference yield:

: 142103-49-9
(S)-4-(2-Benzyloxycarbonylamino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester

: 142103-36-4
<1S-<1R*,2S*,3R*>>-2-amino-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-α-<<2-<(4-morpholinylsulfonyl)amino>-1-oxo-3-phenylpropyl>amino>-5-thiazolebutanamide

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaOH / ethanol / 4 h / Ambient temperature

2: 58 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

3: HCl (gas) / CH₂Cl₂; methanol / Ambient temperature

4: 2.97 g / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC), triethylamine / dimethylformamide / 0 - 20 °C

5: 35 percent / H₂, p-toluenesulfonic acid hydrate / 20percent Pd/C / methanol / 24 h

With hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a006