2-benzhydryl-3-oxo-N,3-diphenylpropanamide

Base Information

• Chemical Name: 2-benzhydryl-3-oxo-N,3-diphenylpropanamide
• CAS No.: 128316-23-4
• Molecular Formula: C₂₈H₂₃NO₂
• Molecular Weight: 405.496
• Mol file: 128316-23-4.mol

Synonyms:2-benzhydryl-3-oxo-N,3-diphenylpropanamide

Chemical Property of 2-benzhydryl-3-oxo-N,3-diphenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-benzhydryl-3-oxo-N,3-diphenylpropanamide

There total 5 articles about 2-benzhydryl-3-oxo-N,3-diphenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Diphenylmethane (101-81-5) + 3-oxo-3-phenylpropionanilide (959-66-0) → 2-benzhydryl-3-oxo-N,3-diphenylpropanamide (128316-23-4)

Guidance literature:

With di-tert-butyl peroxide; iron(II) chloride; at 80 ℃; for 8h;

DOI:10.1002/anie.200701782

Reference yield: 69.0%

N-phenyl-β-diphenylmethylbenzoylpyruvamide (118081-87-1) → 2-benzhydryl-3-oxo-N,3-diphenylpropanamide (128316-23-4)

Guidance literature:

at 200 - 220 ℃; for 0.5h;

Reference yield: 53.0%

N,N-diphenylcinnamamide (50395-70-5) + 2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) → 2-benzhydryl-3-oxo-N,3-diphenylpropanamide (128316-23-4)

Guidance literature:

In acetonitrile; for 1h; UV-irradiation; Inert atmosphere; Green chemistry;

DOI:10.1021/acs.orglett.5b00144

upstream raw materials:

N-phenyl-β-diphenylmethylbenzoylpyruvamide

Diphenylmethane

3-oxo-3-phenylpropionanilide

Cinnamic acid