7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]-N-(2-{2-[2-(2-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}ethoxy)ethoxy]ethoxy}ethyl)-N-methylheptanamide

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Chemical Name:7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]-N-(2-{2-[2-(2-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}ethoxy)ethoxy]ethoxy}ethyl)-N-methylheptanamide
CAS No.:1584647-09-5
Molecular Formula:C₆₀H₇₁Cl₃N₆O₁₀
Molecular Weight:1142.62
Hs Code.:

7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]-N-(2-{2-[2-(2-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}ethoxy)ethoxy]ethoxy}ethyl)-N-methylheptanamide

Synonyms:7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]-N-(2-{2-[2-(2-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}ethoxy)ethoxy]ethoxy}ethyl)-N-methylheptanamide

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Chemical Property of 7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]-N-(2-{2-[2-(2-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}ethoxy)ethoxy]ethoxy}ethyl)-N-methylheptanamide

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Technology Process of 7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]-N-(2-{2-[2-(2-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}ethoxy)ethoxy]ethoxy}ethyl)-N-methylheptanamide

There total 6 articles about 7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]-N-(2-{2-[2-(2-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}ethoxy)ethoxy]ethoxy}ethyl)-N-methylheptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1250437-02-5
C₂₅H₂₉Cl₃N₄O₄

: 1584647-20-0
7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]heptanoic acid

: 1584647-09-5
7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]-N-(2-{2-[2-(2-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}ethoxy)ethoxy]ethoxy}ethyl)-N-methylheptanamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/ml4004759

Reference yield:

: 361388-47-8
N-benzyl-2-{1-[(3-hydroxy-4-methoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide

: 1584647-09-5
7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]-N-(2-{2-[2-(2-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}ethoxy)ethoxy]ethoxy}ethyl)-N-methylheptanamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 50 °C

2: sodium hydroxide; water / ethanol / 20 °C

3: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With water; tetra-(n-butyl)ammonium iodide; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ml4004759

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 1584647-09-5
7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]-N-(2-{2-[2-(2-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]formamido}ethoxy)ethoxy]ethoxy}ethyl)-N-methylheptanamide

Guidance literature:: Multi-step reaction with 7 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: trichlorophosphate / toluene / 2 h / 90 °C

3: sodium tetrahydroborate; methanol / Inert atmosphere; Cooling with ice

4: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 50 °C

6: sodium hydroxide; water / ethanol / 20 °C

7: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With methanol; sodium tetrahydroborate; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In ethanol; N,N-dimethyl-formamide; toluene; 2: |Bischler-Napieralski Reaction;
DOI:10.1021/ml4004759