7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]heptanoic acid

Base Information

Chemical Name:7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]heptanoic acid
CAS No.:1584647-20-0
Molecular Formula:C₃₅H₄₄N₂O₇
Molecular Weight:604.744
Hs Code.:

Synonyms:7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]heptanoic acid

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Chemical Property of 7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]heptanoic acid

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Technology Process of 7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]heptanoic acid

There total 5 articles about 7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1584647-25-5
C₃₇H₄₈N₂O₇

: 1584647-20-0
7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]heptanoic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 20 ℃;
DOI:10.1021/ml4004759

Reference yield:

: 361388-47-8
N-benzyl-2-{1-[(3-hydroxy-4-methoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl}acetamide

: 1584647-20-0
7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]heptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 50 °C

2: sodium hydroxide; water / ethanol / 20 °C

With water; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ml4004759

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 1584647-20-0
7-[4-({2-[(benzylcarbamoyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl}methyl)-2-methoxyphenoxy]heptanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: trichlorophosphate / toluene / 2 h / 90 °C

3: sodium tetrahydroborate; methanol / Inert atmosphere; Cooling with ice

4: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: tetra-(n-butyl)ammonium iodide; potassium carbonate / N,N-dimethyl-formamide / 50 °C

6: sodium hydroxide; water / ethanol / 20 °C

With methanol; sodium tetrahydroborate; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In ethanol; N,N-dimethyl-formamide; toluene; 2: |Bischler-Napieralski Reaction;
DOI:10.1021/ml4004759