4-(4-(3-(3-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)thiazol-2-yl)morpholine

Base Information

Chemical Name:4-(4-(3-(3-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)thiazol-2-yl)morpholine
CAS No.:1613711-21-9
Molecular Formula:C₂₁H₁₉FN₄O₂S
Molecular Weight:410.472
Hs Code.:

Synonyms:4-(4-(3-(3-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)thiazol-2-yl)morpholine

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Chemical Property of 4-(4-(3-(3-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)thiazol-2-yl)morpholine

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Technology Process of 4-(4-(3-(3-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)thiazol-2-yl)morpholine

There total 5 articles about 4-(4-(3-(3-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)thiazol-2-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613712-99-4
C₂₈H₂₅FN₄O₄S₂

: 1613711-21-9
4-(4-(3-(3-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)thiazol-2-yl)morpholine

Guidance literature:: With water; potassium carbonate; In methanol; at 60 ℃;

Reference yield:

: 875639-15-9
5-bromo-3-iodo-1-(4-methylbenzene-1-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1613711-21-9
4-(4-(3-(3-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)thiazol-2-yl)morpholine

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / acetonitrile / 0.25 h / Inert atmosphere; Sealed tube

1.2: 6.25 h / 90 °C / Inert atmosphere

2.1: potassium acetate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 2.17 h / 100 °C / Inert atmosphere

3.1: caesium carbonate / acetonitrile / 0.17 h / Inert atmosphere

3.2: 80 °C / Inert atmosphere; Sealed tube

4.1: potassium carbonate; water / methanol / 60 °C

With water; potassium acetate; potassium carbonate; caesium carbonate; In methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 762287-59-2
(3-fluoro-2-methoxyphenyl)boronic acid

: 1613711-21-9
4-(4-(3-(3-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)thiazol-2-yl)morpholine

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / acetonitrile / 0.25 h / Inert atmosphere; Sealed tube

1.2: 6.25 h / 90 °C / Inert atmosphere

2.1: potassium acetate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 2.17 h / 100 °C / Inert atmosphere

3.1: caesium carbonate / acetonitrile / 0.17 h / Inert atmosphere

3.2: 80 °C / Inert atmosphere; Sealed tube

4.1: potassium carbonate; water / methanol / 60 °C

With water; potassium acetate; potassium carbonate; caesium carbonate; In methanol; N,N-dimethyl-formamide; acetonitrile;