(E)-tert-butyl (5-fluoro-2-(3-(1-methyl-1H-pyrazol-4-yl)acrylamido)phenyl)carbamate

Base Information

• Chemical Name: (E)-tert-butyl (5-fluoro-2-(3-(1-methyl-1H-pyrazol-4-yl)acrylamido)phenyl)carbamate
• CAS No.: 1396722-42-1
• Molecular Formula: C₁₈H₂₁FN₄O₃
• Molecular Weight: 360.388
• Mol file: 1396722-42-1.mol

Synonyms:(E)-tert-butyl (5-fluoro-2-(3-(1-methyl-1H-pyrazol-4-yl)acrylamido)phenyl)carbamate

Chemical Property of (E)-tert-butyl (5-fluoro-2-(3-(1-methyl-1H-pyrazol-4-yl)acrylamido)phenyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-tert-butyl (5-fluoro-2-(3-(1-methyl-1H-pyrazol-4-yl)acrylamido)phenyl)carbamate

There total 3 articles about (E)-tert-butyl (5-fluoro-2-(3-(1-methyl-1H-pyrazol-4-yl)acrylamido)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-amino-4-fluoro-phenyl)carbamic acid tert-butyl ester (579474-47-8) + (E)-3-(1-methyl-1H-pyrazol-4-yl)acrylic acid (689251-97-6) → (E)-tert-butyl (5-fluoro-2-(3-(1-methyl-1H-pyrazol-4-yl)acrylamido)phenyl)carbamate (1396722-42-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

(2-amino-5-fluorophenyl)carbamic acid tert-butyl ester (362670-07-3) + (E)-3-(1-methyl-1H-pyrazol-4-yl)acrylic acid (689251-97-6) → (E)-tert-butyl (5-fluoro-2-(3-(1-methyl-1H-pyrazol-4-yl)acrylamido)phenyl)carbamate (1396722-42-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

methyl (2E)-3-(1-methyl-1H-pyrazol-4-yl)prop-2-enoate (1295583-21-9) → (E)-tert-butyl (5-fluoro-2-(3-(1-methyl-1H-pyrazol-4-yl)acrylamido)phenyl)carbamate (1396722-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol / 70 °C

1.2: pH 4

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In methanol; dichloromethane;

upstream raw materials:

(2-amino-4-fluoro-phenyl)carbamic acid tert-butyl ester

(E)-3-(1-methyl-1H-pyrazol-4-yl)acrylic acid

methyl (2E)-3-(1-methyl-1H-pyrazol-4-yl)prop-2-enoate

(2-amino-5-fluorophenyl)carbamic acid tert-butyl ester

Downstream raw materials:

(E)-N-(2-amino-5-fluorophenyl)-3-(1-methyl-1H-pyrazol-4-yl)acrylamide

(E)-N-(2-amino-4-fluorophenyl)-3-(1-methyl-1H-pyrazol-4-yl)acrylamide