(E)-N-(2-amino-4-fluorophenyl)-3-(1-methyl-1H-pyrazol-4-yl)acrylamide

Base Information

• Chemical Name: (E)-N-(2-amino-4-fluorophenyl)-3-(1-methyl-1H-pyrazol-4-yl)acrylamide
• CAS No.: 1396720-77-6
• Molecular Formula: C₁₃H₁₃FN₄O
• Molecular Weight: 260.271
• Mol file: 1396720-77-6.mol

Synonyms:(E)-N-(2-amino-4-fluorophenyl)-3-(1-methyl-1H-pyrazol-4-yl)acrylamide

Chemical Property of (E)-N-(2-amino-4-fluorophenyl)-3-(1-methyl-1H-pyrazol-4-yl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(2-amino-4-fluorophenyl)-3-(1-methyl-1H-pyrazol-4-yl)acrylamide

There total 4 articles about (E)-N-(2-amino-4-fluorophenyl)-3-(1-methyl-1H-pyrazol-4-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-tert-butyl (4-fluoro-2-(3-(1-methyl-1H-pyrazol-4-yl)acrylamido)phenyl)carbamate (1396722-38-5) → (E)-N-(2-amino-4-fluorophenyl)-3-(1-methyl-1H-pyrazol-4-yl)acrylamide (1396720-77-6)

Guidance literature:

(E)-tert-butyl (4-fluoro-2-(3-(1-methyl-1H-pyrazol-4-yl)acrylamido)phenyl)carbamate; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In 1,4-dioxane;

Reference yield:

(E)-tert-butyl (5-fluoro-2-(3-(1-methyl-1H-pyrazol-4-yl)acrylamido)phenyl)carbamate (1396722-42-1) → (E)-N-(2-amino-4-fluorophenyl)-3-(1-methyl-1H-pyrazol-4-yl)acrylamide (1396720-77-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

Reference yield:

methyl (2E)-3-(1-methyl-1H-pyrazol-4-yl)prop-2-enoate (1295583-21-9) → (E)-N-(2-amino-4-fluorophenyl)-3-(1-methyl-1H-pyrazol-4-yl)acrylamide (1396720-77-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide; water / methanol / 70 °C

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In 1,4-dioxane; methanol; dichloromethane;

upstream raw materials:

(E)-tert-butyl (4-fluoro-2-(3-(1-methyl-1H-pyrazol-4-yl)acrylamido)phenyl)carbamate

methyl (2E)-3-(1-methyl-1H-pyrazol-4-yl)prop-2-enoate

(E)-3-(1-methyl-1H-pyrazol-4-yl)acrylic acid

(E)-tert-butyl (5-fluoro-2-(3-(1-methyl-1H-pyrazol-4-yl)acrylamido)phenyl)carbamate