N-(2,4-dimethoxybenzyl)-N-(bromoaceto)acetyl-O-tert-butyldimethylsilyl-L-tyrosine methyl ester

Base Information

Chemical Name:N-(2,4-dimethoxybenzyl)-N-(bromoaceto)acetyl-O-tert-butyldimethylsilyl-L-tyrosine methyl ester
CAS No.:1257083-01-4
Molecular Formula:C₂₉H₄₀BrNO₇Si
Molecular Weight:622.629
Hs Code.:

Synonyms:N-(2,4-dimethoxybenzyl)-N-(bromoaceto)acetyl-O-tert-butyldimethylsilyl-L-tyrosine methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2,4-dimethoxybenzyl)-N-(bromoaceto)acetyl-O-tert-butyldimethylsilyl-L-tyrosine methyl ester

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Technology Process of N-(2,4-dimethoxybenzyl)-N-(bromoaceto)acetyl-O-tert-butyldimethylsilyl-L-tyrosine methyl ester

There total 1 articles about N-(2,4-dimethoxybenzyl)-N-(bromoaceto)acetyl-O-tert-butyldimethylsilyl-L-tyrosine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 674-82-8,2130-41-8
4-methyleneoxetan-2-one

: 1257082-97-5
methyl (2S)-3-{4'-[(tert-butyldimethylsilyl)oxy]phenyl}-2-[(1'',5''-dimethoxybenzyl)amino]propanoate

: 1257083-01-4
N-(2,4-dimethoxybenzyl)-N-(bromoaceto)acetyl-O-tert-butyldimethylsilyl-L-tyrosine methyl ester

Guidance literature:: 4-methyleneoxetan-2-one; With bromine; In dichloromethane; at -40 ℃; for 1h; Inert atmosphere;

methyl (2S)-3-{4'-[(tert-butyldimethylsilyl)oxy]phenyl}-2-[(1'',5''-dimethoxybenzyl)amino]propanoate; With triethylamine; In dichloromethane; at -40 - -20 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201000597

Reference yield:

: 1257083-01-4
N-(2,4-dimethoxybenzyl)-N-(bromoaceto)acetyl-O-tert-butyldimethylsilyl-L-tyrosine methyl ester

: 762-04-9
phosphonic acid diethyl ester

: C₃₂H₄₄NO₉PSi^(2-)*2K⁽¹⁺⁾

Guidance literature:: phosphonic acid diethyl ester; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.333333h; Inert atmosphere;

N-(2,4-dimethoxybenzyl)-N-(bromoaceto)acetyl-O-tert-butyldimethylsilyl-L-tyrosine methyl ester; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/ejoc.201000597