3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-methoxybenzaldehyde

Base Information

• Chemical Name: 3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-methoxybenzaldehyde
• CAS No.: 1424869-81-7
• Molecular Formula: C₁₆H₁₄O₄
• Molecular Weight: 270.285
• Mol file: 1424869-81-7.mol

Synonyms:3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-methoxybenzaldehyde

Chemical Property of 3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-methoxybenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-methoxybenzaldehyde

There total 2 articles about 3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2.3-dihydro-1,4-benzodioxin-6-ylboronic acid (164014-95-3) + 3-bromo-5-methoxybenzaldehyde (262450-65-7) → 3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-methoxybenzaldehyde (1424869-81-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; In 1,4-dioxane; at 80 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.01.008

Reference yield: 85.0%

1-(3-bromo-5-methoxyphenyl)ethanone (1073642-71-3) + 2.3-dihydro-1,4-benzodioxin-6-ylboronic acid (164014-95-3) → 3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-methoxybenzaldehyde (1424869-81-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; In 1,4-dioxane; at 80 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.01.008

Reference yield:

3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-methoxybenzaldehyde (1424869-81-7) + (methoxymethyl)triphenylphosphonium chloride (4009-98-7) → C18H18O4

Guidance literature:

(methoxymethyl)triphenylphosphonium chloride; With sodium t-butanolate; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-methoxybenzaldehyde; In tetrahydrofuran; for 0.333333h; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.01.008

upstream raw materials:

2.3-dihydro-1,4-benzodioxin-6-ylboronic acid

3-bromo-5-methoxybenzaldehyde

1-(3-bromo-5-methoxyphenyl)ethanone

Downstream raw materials:

C₂₄H₂₄N₄O₃

6-(3-methoxy-5-prop-2-ynylphenyl)-2,3-dihydro-benzo[1,4]dioxine