methyl 2-(2-(2-(2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

Base Information

Chemical Name:methyl 2-(2-(2-(2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate
CAS No.:1393653-49-0
Molecular Formula:C₁₇H₁₇F₃N₂O₄S
Molecular Weight:402.394
Hs Code.:

Synonyms:methyl 2-(2-(2-(2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

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Chemical Property of methyl 2-(2-(2-(2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

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Technology Process of methyl 2-(2-(2-(2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

There total 9 articles about methyl 2-(2-(2-(2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1393653-52-5
methyl 2-(2-((2-(methylsulfonyl )-5-(trifluoromethyl)pyrimidin-4-yl)ethynyl)phenyl)acetate

: 1393653-49-0
methyl 2-(2-(2-(2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 66370-75-0
methyl (2-iodophenyl)acetate

: 1393653-49-0
methyl 2-(2-(2-(2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / dichloromethane; tetrahydrofuran / 1 h / 0 - 20 °C

3: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.17 h / 100 °C / Inert atmosphere; microwave irradiation

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 16 h / 20 °C

With tetrabutyl ammonium fluoride; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 1393653-49-0
methyl 2-(2-(2-(2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc(II) chloride / diethyl ether; tetrahydrofuran / 2 h / Cooling with ice; Inert atmosphere

1.2: 20 °C

2.1: sodium iodide; hydrogen iodide / 48 h / Darkness

3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 0.17 h / 100 °C / Inert atmosphere; microwave irradiation

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 16 h / 20 °C

With hydrogen iodide; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; zinc(II) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;