dimethyl-carbamic acid 4-methyl-3-(3-nitrobenzyl)-2-oxo-2H-pyrano[2,3-b]pyridin-7-yl ester

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Chemical Name:dimethyl-carbamic acid 4-methyl-3-(3-nitrobenzyl)-2-oxo-2H-pyrano[2,3-b]pyridin-7-yl ester
CAS No.:946132-31-6
Molecular Formula:C₁₉H₁₇N₃O₆
Molecular Weight:383.36
Hs Code.:

Synonyms:dimethyl-carbamic acid 4-methyl-3-(3-nitrobenzyl)-2-oxo-2H-pyrano[2,3-b]pyridin-7-yl ester

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Chemical Property of dimethyl-carbamic acid 4-methyl-3-(3-nitrobenzyl)-2-oxo-2H-pyrano[2,3-b]pyridin-7-yl ester

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Technology Process of dimethyl-carbamic acid 4-methyl-3-(3-nitrobenzyl)-2-oxo-2H-pyrano[2,3-b]pyridin-7-yl ester

There total 4 articles about dimethyl-carbamic acid 4-methyl-3-(3-nitrobenzyl)-2-oxo-2H-pyrano[2,3-b]pyridin-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 946125-89-9
7-hydroxy-4-methyl-3-(3-nitrobenzyl)-pyrano[2,3-b]pyridin-2-one

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 946132-31-6
dimethyl-carbamic acid 4-methyl-3-(3-nitrobenzyl)-2-oxo-2H-pyrano[2,3-b]pyridin-7-yl ester

Guidance literature:: 7-hydroxy-4-methyl-3-(3-nitrobenzyl)-pyrano[2,3-b]pyridin-2-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h;

N,N-Dimethylcarbamoyl chloride; In N,N-dimethyl-formamide; mineral oil; at 100 ℃; for 2h;
DOI:10.1021/ml400379x

Reference yield:

: 626-06-2
2,6-dihydroxypyridine

: 946132-31-6
dimethyl-carbamic acid 4-methyl-3-(3-nitrobenzyl)-2-oxo-2H-pyrano[2,3-b]pyridin-7-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc trifluoromethanesulfonate / methanol / 30 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

2.2: 2 h / 100 °C

With zinc trifluoromethanesulfonate; sodium hydride; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ml400379x

Reference yield:

: 393812-70-9
2-(3-nitrobenzyl)-3-oxo-butyric acid ethyl ester

: 946132-31-6
dimethyl-carbamic acid 4-methyl-3-(3-nitrobenzyl)-2-oxo-2H-pyrano[2,3-b]pyridin-7-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc trifluoromethanesulfonate / methanol / 30 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

2.2: 2 h / 100 °C

With zinc trifluoromethanesulfonate; sodium hydride; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ml400379x