(R)-2-((2-(3-aminopiperidin-1-yl)-5-((4-methylquinazolin-2-yl)methyl)-4-oxo-4,5,7,8-tetrahydro-3H-imidazo[2,1-b]purin-3-yl)methyl)benzonitrile

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Chemical Name:(R)-2-((2-(3-aminopiperidin-1-yl)-5-((4-methylquinazolin-2-yl)methyl)-4-oxo-4,5,7,8-tetrahydro-3H-imidazo[2,1-b]purin-3-yl)methyl)benzonitrile
CAS No.:1381795-07-8
Molecular Formula:C₃₀H₃₀N₁₀O
Molecular Weight:546.635
Hs Code.:

Synonyms:(R)-2-((2-(3-aminopiperidin-1-yl)-5-((4-methylquinazolin-2-yl)methyl)-4-oxo-4,5,7,8-tetrahydro-3H-imidazo[2,1-b]purin-3-yl)methyl)benzonitrile

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Chemical Property of (R)-2-((2-(3-aminopiperidin-1-yl)-5-((4-methylquinazolin-2-yl)methyl)-4-oxo-4,5,7,8-tetrahydro-3H-imidazo[2,1-b]purin-3-yl)methyl)benzonitrile

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Technology Process of (R)-2-((2-(3-aminopiperidin-1-yl)-5-((4-methylquinazolin-2-yl)methyl)-4-oxo-4,5,7,8-tetrahydro-3H-imidazo[2,1-b]purin-3-yl)methyl)benzonitrile

There total 9 articles about (R)-2-((2-(3-aminopiperidin-1-yl)-5-((4-methylquinazolin-2-yl)methyl)-4-oxo-4,5,7,8-tetrahydro-3H-imidazo[2,1-b]purin-3-yl)methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₃₈N₁₀O₃

: 1381795-07-8
(R)-2-((2-(3-aminopiperidin-1-yl)-5-((4-methylquinazolin-2-yl)methyl)-4-oxo-4,5,7,8-tetrahydro-3H-imidazo[2,1-b]purin-3-yl)methyl)benzonitrile

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2016.09.007

Reference yield:

: 1381795-10-3
2-(2-chloro-7-(4-methoxybenzyl)-6-oxo-6,7-dihydro-1H-purin-1-yl)acetonitrile

: 1381795-07-8
(R)-2-((2-(3-aminopiperidin-1-yl)-5-((4-methylquinazolin-2-yl)methyl)-4-oxo-4,5,7,8-tetrahydro-3H-imidazo[2,1-b]purin-3-yl)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / 1,4-dioxane / 7 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0.5 h / 125 °C / Inert atmosphere; Microwave irradiation

3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 5 h / Inert atmosphere

4.1: trifluoroacetic acid / 70 °C / Sealed tube

5.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2.5 h / 0 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 100 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.09.007

Reference yield:

: 1381795-16-9
2-bromo-5-((4-methylquinazolin-2-yl)methyl)-7,8-dihydro-3H-imidazo[2,1-b]purin-4(5H)-one

: 1381795-07-8
(R)-2-((2-(3-aminopiperidin-1-yl)-5-((4-methylquinazolin-2-yl)methyl)-4-oxo-4,5,7,8-tetrahydro-3H-imidazo[2,1-b]purin-3-yl)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.09.007