2-(2-chloro-7-(4-methoxybenzyl)-6-oxo-6,7-dihydro-1H-purin-1-yl)acetonitrile

Base Information

Chemical Name:2-(2-chloro-7-(4-methoxybenzyl)-6-oxo-6,7-dihydro-1H-purin-1-yl)acetonitrile
CAS No.:1381795-10-3
Molecular Formula:C₁₅H₁₂ClN₅O₂
Molecular Weight:329.746
Hs Code.:

Synonyms:2-(2-chloro-7-(4-methoxybenzyl)-6-oxo-6,7-dihydro-1H-purin-1-yl)acetonitrile

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Chemical Property of 2-(2-chloro-7-(4-methoxybenzyl)-6-oxo-6,7-dihydro-1H-purin-1-yl)acetonitrile

Chemical Property:

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Technology Process of 2-(2-chloro-7-(4-methoxybenzyl)-6-oxo-6,7-dihydro-1H-purin-1-yl)acetonitrile

There total 3 articles about 2-(2-chloro-7-(4-methoxybenzyl)-6-oxo-6,7-dihydro-1H-purin-1-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1381795-09-0
2-chloro-7-(4-methoxybenzyl)-1H-purin-6(7H)-one

: 107-14-2
chloroacetonitrile

: 1381795-10-3
2-(2-chloro-7-(4-methoxybenzyl)-6-oxo-6,7-dihydro-1H-purin-1-yl)acetonitrile

Guidance literature:: 2-chloro-7-(4-methoxybenzyl)-1H-purin-6(7H)-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 55 ℃; for 3h; Inert atmosphere;

chloroacetonitrile; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2016.09.007

Reference yield:

: 2,6-dichloro-9H-purine

: 1381795-10-3
2-(2-chloro-7-(4-methoxybenzyl)-6-oxo-6,7-dihydro-1H-purin-1-yl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

2.1: sodium hydroxide / water / 1.5 h / 90 °C

2.2: 20 °C / pH 7

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3.17 h / 0 - 55 °C

3.2: 0 °C

With sodium hydride; potassium carbonate; sodium hydroxide; In water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1381795-10-3
2-(2-chloro-7-(4-methoxybenzyl)-6-oxo-6,7-dihydro-1H-purin-1-yl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

2.1: sodium hydroxide / water / 1.5 h / 90 °C

2.2: 20 °C / pH 7

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3.17 h / 0 - 55 °C

3.2: 0 °C

With sodium hydride; potassium carbonate; sodium hydroxide; In water; N,N-dimethyl-formamide; mineral oil;