2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionamide

Base Information

Chemical Name:2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionamide
CAS No.:147961-19-1
Molecular Formula:C₃₅H₃₄ClN₃O₃S
Molecular Weight:612.192
Hs Code.:

Synonyms:2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionamide

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Chemical Property of 2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionamide

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Technology Process of 2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionamide

There total 6 articles about 2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147961-18-0
2-{2-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-ethoxy}-propionic acid ethyl ester

: 147961-19-1
2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionamide

Guidance literature:: With dimethylaluminium amide; In hexane; dichloromethane; m-xylene; at 75 ℃; for 2h;
DOI:10.1021/jm00034a013

Reference yield:

: 155143-17-2
ethyl <1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>acetate

: 147961-19-1
2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 19 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

2: Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

3: 1.) NaH, 2.) n-Bu₄NI / 1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, 18 h

4: dimethylaluminum amide / m-xylene; hexane; CH₂Cl₂ / 2 h / 75 °C

With lithium aluminium tetrahydride; dimethylaluminium amide; tetra-(n-butyl)ammonium iodide; sodium hydride; caesium carbonate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; m-xylene; acetonitrile;
DOI:10.1021/jm00034a013

Reference yield:

: [5-Allyloxy-3-tert-butylsulfanyl-1-(4-chloro-benzyl)-1H-indol-2-yl]-acetic acid ethyl ester

: 147961-19-1
2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: 2.) p-TSA / 1.) 1,2-dichlorobenzene, 200 deg C, 7 h, 2.) 1,2-dichlorobenzene, 150 deg C, 30 min

2: 19 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

3: Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

4: 1.) NaH, 2.) n-Bu₄NI / 1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, 18 h

5: dimethylaluminum amide / m-xylene; hexane; CH₂Cl₂ / 2 h / 75 °C

With lithium aluminium tetrahydride; dimethylaluminium amide; tetra-(n-butyl)ammonium iodide; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; m-xylene; acetonitrile;
DOI:10.1021/jm00034a013