2-[8-fluoro-2-(2-formyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

Base Information

Chemical Name:2-[8-fluoro-2-(2-formyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile
CAS No.:1360056-36-5
Molecular Formula:C₃₅H₃₀FN₇O₅
Molecular Weight:647.666
Hs Code.:

2-[8-fluoro-2-(2-formyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

Synonyms:2-[8-fluoro-2-(2-formyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

Suppliers and Price of 2-[8-fluoro-2-(2-formyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[8-fluoro-2-(2-formyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[8-fluoro-2-(2-formyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

There total 13 articles about 2-[8-fluoro-2-(2-formyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28314-80-9
2,4,6-trifluorobenzoic acid

: 1360056-36-5
2-[8-fluoro-2-(2-formyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 11 steps

1.1: dichloromethane / 0 - 20 °C

2.1: thionyl chloride / dichloromethane / 20 °C / Cooling with ice bath

3.1: diethyl ether; tetrahydrofuran / 0 - 20 °C

4.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / -20 - 15 °C / Inert atmosphere

5.1: acetonitrile / 63 °C

6.1: sodium hydroxide; water / methanol / 1 h / 80 °C

6.2: pH 1

7.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2.75 h

7.2: 4 h

8.1: tetrahydrofuran / 3 h / 63 °C

9.1: potassium tert-butylate / tetrahydrofuran / 2.25 h / 55 - 62 °C

10.1: sodium hydrogencarbonate; copper(l) iodide / ethyl acetate; dimethyl sulfoxide / 3.5 h / 110 °C / Inert atmosphere

11.1: potassium carbonate / tricyclohexylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

With copper(l) iodide; thionyl chloride; potassium tert-butylate; water; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; toluene; acetonitrile; butan-1-ol;

Reference yield:

: 827587-90-6
(6-aminopyridin-3-yl)(morpholin-4-yl)methanone

: 1360056-36-5
2-[8-fluoro-2-(2-formyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 90 °C / Inert atmosphere

2: potassium acetate / palladium diacetate; XPhos / 1,4-dioxane / 0.27 h / 100 °C / Inert atmosphere

3: potassium carbonate / tricyclohexylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

With potassium acetate; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; tricyclohexylphosphine; In 1,4-dioxane; water; butan-1-ol;

Reference yield:

: 1178884-53-1
4-bromo-6-chloro-2-methylpyridazin-3(2H)-one

: 1360056-36-5
2-[8-fluoro-2-(2-formyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 90 °C / Inert atmosphere

2: potassium acetate / palladium diacetate; XPhos / 1,4-dioxane / 0.27 h / 100 °C / Inert atmosphere

3: potassium carbonate / tricyclohexylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

With potassium acetate; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; tricyclohexylphosphine; In 1,4-dioxane; water; butan-1-ol;