2-[8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

Base Information

Chemical Name:2-[8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile
CAS No.:1360055-16-8
Molecular Formula:C₃₅H₃₂FN₇O₅
Molecular Weight:649.681
Hs Code.:

2-[8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

Synonyms:2-[8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

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Chemical Property of 2-[8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

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Technology Process of 2-[8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

There total 15 articles about 2-[8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360056-36-5
2-[8-fluoro-2-(2-formyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

: 1360055-16-8
2-[8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

Guidance literature:: With methanol; sodium tetrahydroborate; water; In dichloromethane; Cooling with ice bath;

Reference yield:

: 28314-80-9
2,4,6-trifluorobenzoic acid

: 1360055-16-8
2-[8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 12 steps

1.1: dichloromethane / 0 - 20 °C

2.1: thionyl chloride / dichloromethane / 20 °C / Cooling with ice bath

3.1: diethyl ether; tetrahydrofuran / 0 - 20 °C

4.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / -20 - 15 °C / Inert atmosphere

5.1: acetonitrile / 63 °C

6.1: sodium hydroxide; water / methanol / 1 h / 80 °C

6.2: pH 1

7.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2.75 h

7.2: 4 h

8.1: tetrahydrofuran / 3 h / 63 °C

9.1: potassium tert-butylate / tetrahydrofuran / 2.25 h / 55 - 62 °C

10.1: sodium hydrogencarbonate; copper(l) iodide / ethyl acetate; dimethyl sulfoxide / 3.5 h / 110 °C / Inert atmosphere

11.1: potassium carbonate / tricyclohexylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

12.1: water; sodium tetrahydroborate; methanol / dichloromethane / Cooling with ice bath

With methanol; sodium tetrahydroborate; copper(l) iodide; thionyl chloride; potassium tert-butylate; water; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; toluene; acetonitrile; butan-1-ol;

Reference yield:

: 1178884-53-1
4-bromo-6-chloro-2-methylpyridazin-3(2H)-one

: 1360055-16-8
2-[8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 90 °C / Inert atmosphere

2: potassium acetate / palladium diacetate; XPhos / 1,4-dioxane / 0.27 h / 100 °C / Inert atmosphere

3: potassium carbonate / tricyclohexylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

4: water; sodium tetrahydroborate; methanol / dichloromethane / Cooling with ice bath

With methanol; sodium tetrahydroborate; water; potassium acetate; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane; water; butan-1-ol;