[(S)-1-(4-tert-Butoxy-benzyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: [(S)-1-(4-tert-Butoxy-benzyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester
• CAS No.: 187527-00-0
• Molecular Formula: C₃₆H₃₄N₂O₅
• Molecular Weight: 574.676

Synonyms:[(S)-1-(4-tert-Butoxy-benzyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property of [(S)-1-(4-tert-Butoxy-benzyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-1-(4-tert-Butoxy-benzyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 2 articles about [(S)-1-(4-tert-Butoxy-benzyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

phthalimide (136918-14-4,85-41-6) + (9H-fluoren-9-yl)methyl (S)-(1-(4-(tert-butoxy)phenyl)-3-hydroxypropan-2-yl)carbamate (187526-99-4) → [(S)-1-(4-tert-Butoxy-benzyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (187527-00-0)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo051226t

Reference yield:

Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) → [(S)-1-(4-tert-Butoxy-benzyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (187527-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) isobutyl chloroformate, triethylamine, 2.) NaBH₄ / 1.) THF, 0 deg C, 2.) water

2: 2.4 g / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 3 h / 25 °C

With sodium tetrahydroborate; triethylamine; triphenylphosphine; diethylazodicarboxylate; isobutyl chloroformate; In tetrahydrofuran;

DOI:10.1021/ja9631256

Reference yield: 56.0%

[(S)-1-(4-tert-Butoxy-benzyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (187527-00-0) → 2-[(S)-2-Amino-3-(4-tert-butoxy-phenyl)-propyl]-isoindole-1,3-dione (187527-01-1)

Guidance literature:

With diethylamine; In tetrahydrofuran; at 25 ℃; for 12h;

DOI:10.1021/ja9631256

upstream raw materials:

phthalimide

(9H-fluoren-9-yl)methyl (S)-(1-(4-(tert-butoxy)phenyl)-3-hydroxypropan-2-yl)carbamate

Fmoc-Tyr(tBu)-OH

Downstream raw materials:

2-[(S)-2-Amino-3-(4-tert-butoxy-phenyl)-propyl]-isoindole-1,3-dione

2-[2-azido-3-(4-tert-butoxy-phenyl)-propyl]-isoindole-1,3-dione

C₂₇H₃₇N₅O₄S₂

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 187527-00-0 [(S)-1-(4-tert-Butoxy-benzyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send